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Case Reports
. 2023 Jun 8;8(9):1892-1898.
doi: 10.1016/j.ekir.2023.06.001. eCollection 2023 Sep.

Membranous Nephropathy After Exposure to Immune Checkpoint Inhibitors

Rayane Benyahia  1 , Helene Lazareth  2   3 , Adrien Flahault  2   3 , Vesna Brglez  4   5   6 , Barbara Seitz-Polski  4   5   6   7 , Samy El Fil  8 , Julien Mazières  9   10 , David Ribes  1 , Antoine Huart  1 , Magali Colombat  10   11 , Alexandre Karras  2   3 , Julie Belliere  1   10
Affiliations
Case Reports

Membranous Nephropathy After Exposure to Immune Checkpoint Inhibitors

Rayane Benyahia et al. Kidney Int Rep. .
No abstract available

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Figures

Figure 1
Figure 1
Kidney biopsy from Case Number 1, confirming the diagnosis of anti-PLA2R ICI-associated MN and unraveling a full-house immunofluorescent pattern. (a) Masson’s trichrome staining (40× magnification). (b) Jones staining (×40 magnification). (c) Immunofluorescence for IgG (×40 magnification), IgA (×40 magnification), IgM (×40 magnification), C3 (×40 magnification), C1q (×40 magnification), kappa (×40 magnification), and lambda (×40 magnification) showing subepithelial deposition of IgG, IgA, IgM, C3, C1q, kappa light chains, and lambda light chains.
Figure 2
Figure 2
Anti-PLA2R ICI-associated MN evolution under rituximab therapy in Case Number 1. (a) Antiphospholipase A2 receptor (PLA2R) antibody titer over time (RU/ml). (b) Analysis of PLA2R domain recognition indicated that the anti-PLA2R epitope recognition was restricted to the CysR domain (RU/ml). (c) Serum albumin (g/l) and urine protein-to-creatinine ratio (g/g) over time. (d) creatininemia (μmol/l) over time.
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