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. 2023 Aug 13;15(8):e43419.
doi: 10.7759/cureus.43419. eCollection 2023 Aug.

Model of Anti-Mullerian Hormone Over Age to Predict Menopause in Polycystic Ovary Syndrome and Eumenorrheic Women: A Study on Southern Indian Population

Hassan Mohammad  1 , Janaki C S  2 , Geetha Haripriya  3 , Dinesh Maskeri  4 , Prabhu K  5 , Padma Priya  6
Affiliations

Model of Anti-Mullerian Hormone Over Age to Predict Menopause in Polycystic Ovary Syndrome and Eumenorrheic Women: A Study on Southern Indian Population

Hassan Mohammad et al. Cureus. .

Abstract

Introduction Anti-mullerian hormone (AMH) is a member of the transforming growth factor β family and is a marker of ovarian reserve; it is produced by the granulosa cells of developing preantral and early antral ovarian follicles. AMH concentration decreases with increasing age. Its concentration is increased relatively in those with polycystic ovary syndrome (PCOS) than eumenorrheic women. Objectives In this research, using a model of AMH over age, the age of menopause is predicted in PCOS and eumenorrheic women. Study design The study subjects were classified into two groups. Group 1 included PCOS subjects. Group 2 included eumenorrheic women. General profiles such as age, BMI, and hormonal parameters such as AMH were measured. Based on the exponential functional dependence of AMH over age, a model was proposed, and the value of exponential constants such as log βo and β1 were calculated using least square approximation. An arbitrary value of 0.2 ng/mL for AMH was taken as a cut-off value to predict the age of menopause in both groups. Outcome measures We predicted the age of menopause using a model of AMH over age by the least square approximation technique. Results The age prediction for menopause using the least squares model of AMH over age showed that in group 1 patients with PCOS, menopause is projected to occur at around 54.7 years, while in group 2 with eumenorrheic women, it is expected to happen at approximately 45.2 years. Conclusion Data demonstrates that serum AMH concentration declines over time, and predicting the age of menopause reflects sustained reproductive life span in PCOS subjects.

Keywords: anti-mullerian hormone; least squares model; menopause; ovarian reserve; polycystic ovarian syndrome.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Curve rate of decline between AMH and age in eumenorrheic women. AMH and age are shown in the y-axis and x-axis, respectively.
AMH, anti-mullerian hormone; PCOS, polycystic ovary syndrome
Figure 2
Figure 2. Curve rate of decline between AMH and age in PCOS women. AMH and age are shown in the y-axis and x-axis, respectively.
AMH, anti-mullerian hormone; PCOS, polycystic ovary syndrome
See this image and copyright information in PMC

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