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. 2024 Feb 1;19(2):260-262.
doi: 10.2215/CJN.0000000000000323. Epub 2023 Sep 14.

Using Restricted Mean Survival Time to Improve Interpretability of Time-to-Event Data Analysis

Vivek Charu  1   2 , Lu Tian  3 , Manjula Kurella Tamura  4   5 , Maria E Montez-Rath  5
Affiliations

Using Restricted Mean Survival Time to Improve Interpretability of Time-to-Event Data Analysis

Vivek Charu et al. Clin J Am Soc Nephrol. .
No abstract available

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Conflict of interest statement

M. Kurella Tamura reports employment with VA Palo Alto Health Care System, honoraria from American Federation for Aging Research, role as an Associate Editor of CJASN, and advisory or leadership roles for Beeson External Advisory Committee and Clin-Star Advisory Board. L. Tian reports employment with Gilead Inc., consultancy for Athersys Inc. and Biogen Inc., and ownership interest in Gilead Inc. All remaining authors have nothing to disclose.

Figures

Figure 1
Figure 1
RMST estimates in the intensive and standard systolic BP target arms in SPRINT. The 4-year RMST, or average MACE-free days in 4 years, in the intensive systolic BP group is 1409 days (pink-shaded area), compared with 1394 average MACE-free days in 4 years in the standard systolic BP group (blue-shaded area; purple where the two overlap). The 4-year RMST difference between the intensive and standard systolic BP groups, a measure of treatment effect, is 15 days (95% CI, 6 to 25 days; P = 0.002). This measure of treatment effect has the following interpretation: On average, intensive BP control delays MACE by 15 days over 4 years compared with standard BP control. The RMST difference also has a geometric interpretation as the area between two survival curves. CI, confidence interval; MACE, major adverse cardiovascular event; RMST, restricted mean survival time; SPRINT, Systolic Blood Pressure Intervention Trial.
See this image and copyright information in PMC

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