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Case Reports
. 2023 Sep;28(37):2300456.
doi: 10.2807/1560-7917.ES.2023.28.37.2300456.

Two cases of extensively drug-resistant (XDR) Neisseria gonorrhoeae infection combining ceftriaxone-resistance and high-level azithromycin resistance, France, November 2022 and May 2023

Clara Maubaret  1   2   3   4 , François Caméléna  1   2   3   4 , Manel Mrimèche  1   3   4 , Aymeric Braille  3   4 , Mathilde Liberge  1   3   4 , Mary Mainardis  3   4 , Clémence Guillaume  5 , Franck Noel  6 , Cécile Bébéar  7   8 , Jean-Michel Molina  9   10 , Florence Lot  11 , Emilie Chazelle  11 , Béatrice Berçot  1   3   4
Affiliations
Case Reports

Two cases of extensively drug-resistant (XDR) Neisseria gonorrhoeae infection combining ceftriaxone-resistance and high-level azithromycin resistance, France, November 2022 and May 2023

Clara Maubaret et al. Euro Surveill. 2023 Sep.

Abstract

We report two extensively drug-resistant (XDR) Neisseria gonorrhoeae (NG) isolates combining high-level resistance to azithromycin and resistance to ceftriaxone, obtained in France from two heterosexual patients, one of whom returned from Cambodia. Whole genome sequencing identified MLST ST16406, the mosaic penA-60.001 which caused ceftriaxone resistance in the internationally spreading FC428 clone, and the A2059G mutation in the 23S rRNA gene. The NG isolates F93 and F94 were related to XDR isolates detected in Austria and the United Kingdom in 2022.

Keywords: XDR, gonorrhea, penA-60.001, A2059G mutation, France; bacterial infections; gonorrhoea; laboratory; laboratory surveillance; molecular methods; multidrug resistance; sexually transmitted infections; typing.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure
Figure
Ceftriaxone-resistant and high-level azithromycin-resistant Neisseria gonorrhoeae isolates, including the XDR-F93 and -F94 isolates from France, November 2022 and May 2023
See this image and copyright information in PMC

References

    1. Tapsall JW, Ndowa F, Lewis DA, Unemo M. Meeting the public health challenge of multidrug- and extensively drug-resistant Neisseria gonorrhoeae. Expert Rev Anti Infect Ther. 2009;7(7):821-34. 10.1586/eri.09.63 - DOI - PubMed
    1. Cole MJ, Day M, Jacobsson S, Amato-Gauci AJ, Spiteri G, Unemo M, et al. The European response to control and manage multi- and extensively drug-resistant Neisseria gonorrhoeae. Euro Surveill. 2022;27(18):2100611. 10.2807/1560-7917.ES.2022.27.18.2100611 - DOI - PMC - PubMed
    1. Day M, Pitt R, Mody N, Saunders J, Rai R, Nori A, et al. Detection of 10 cases of ceftriaxone-resistant Neisseria gonorrhoeae in the United Kingdom, December 2021 to June 2022. Euro Surveill. 2022;27(46):2200803. 10.2807/1560-7917.ES.2022.27.46.2200803 - DOI - PMC - PubMed
    1. Pleininger S, Indra A, Golparian D, Heger F, Schindler S, Jacobsson S, et al. Extensively drug-resistant (XDR) Neisseria gonorrhoeae causing possible gonorrhoea treatment failure with ceftriaxone plus azithromycin in Austria, April 2022. Euro Surveill. 2022;27(24):1-5. 10.2807/1560-7917.ES.2022.27.24.2200455 - DOI - PMC - PubMed
    1. Brun J-L, Castan B, de Barbeyrac B, Cazanave C, Charvériat A, Faure K, et al. Pelvic inflammatory diseases: Updated French guidelines. J Gynecol Obstet Hum Reprod. 2020;49(5):101714. 10.1016/j.jogoh.2020.101714 - DOI - PubMed

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