Preliminary results on an autochthonous dengue outbreak in Lombardy Region, Italy, August 2023

doi:10.2807/1560-7917.ES.2023.28.37.2300471

. 2023 Sep;28(37):2300471.

doi: 10.2807/1560-7917.ES.2023.28.37.2300471.

Preliminary results on an autochthonous dengue outbreak in Lombardy Region, Italy, August 2023

Irene Cassaniti^{1

2

3}, Guglielmo Ferrari^{2

3}, Sabrina Senatore⁴, Eva Rossetti⁴, Francesco Defilippo⁵, Manuel Maffeo^{6

7}, Luigi Vezzosi^{7

8}, Giulia Campanini³, Antonella Sarasini³, Stefania Paolucci³, Antonio Piralla³, Davide Lelli⁵, Ana Moreno⁵, Maira Bonini⁴, Marcello Tirani^{8

9}, Lorenzo Cerutti¹⁰, Stefano Paglia¹¹, Angelo Regazzetti¹², Marco Farioli⁸, Antonio Lavazza⁵, Marino Faccini⁴, Francesca Rovida^{1

3}, Danilo Cereda^{13

8}, Fausto Baldanti^{1

13

3}; Lombardy Dengue network¹⁴; Lombardy Dengue Network

Collaborators, Affiliations

Affiliations

¹ Department of Clinical, Surgical, Diagnostic and Paediatric Sciences, University of Pavia, Pavia, Italy.
² These authors contributed equally to this work and share first authorship.
³ SC Microbiology and Virology, IRCCS Policlinico San Matteo, Pavia, Italy.
⁴ Department of Hygiene and Health Prevention, Health Protection Agency, Metropolitan Area of Milan, Milan, Italy.
⁵ Virology Department, Istituto Zooprofilattico Sperimentale della Lombardia ed Emilia Romagna, Brescia, Italy.
⁶ Postgraduate School in Public Health, Department Biomedical Sciences for Health, University of Milan, Milan, Italy.
⁷ Department of Hygiene and Health Prevention, Health Protection Agency Val Padana, Mantova, Italy.
⁸ General Directorate of Welfare, Regione Lombardia, Milan, Italy.
⁹ Health Director Staff, Health Protection Agency, Metropolitan Area of Milan, Milan, Italy.
¹⁰ SC Chemical-Clinical Analysis and Microbiology Laboratory, ASST Lodi, Lodi, Italy.
¹¹ Department of Emergency and Urgency, ASST Lodi, Lodi, Italy.
¹² SC Infectious and Tropical Diseases, ASST Lodi, Lodi, Italy.
¹³ These authors contributed equally to this work and share last authorship.
¹⁴ The members of the network are listed under Collaborators.

PMID: 37707980
PMCID: PMC10687988
DOI: 10.2807/1560-7917.ES.2023.28.37.2300471

Preliminary results on an autochthonous dengue outbreak in Lombardy Region, Italy, August 2023

Irene Cassaniti et al. Euro Surveill. 2023 Sep.

. 2023 Sep;28(37):2300471.

doi: 10.2807/1560-7917.ES.2023.28.37.2300471.

Authors

Affiliations

¹ Department of Clinical, Surgical, Diagnostic and Paediatric Sciences, University of Pavia, Pavia, Italy.
² These authors contributed equally to this work and share first authorship.
³ SC Microbiology and Virology, IRCCS Policlinico San Matteo, Pavia, Italy.
⁴ Department of Hygiene and Health Prevention, Health Protection Agency, Metropolitan Area of Milan, Milan, Italy.
⁵ Virology Department, Istituto Zooprofilattico Sperimentale della Lombardia ed Emilia Romagna, Brescia, Italy.
⁶ Postgraduate School in Public Health, Department Biomedical Sciences for Health, University of Milan, Milan, Italy.
⁷ Department of Hygiene and Health Prevention, Health Protection Agency Val Padana, Mantova, Italy.
⁸ General Directorate of Welfare, Regione Lombardia, Milan, Italy.
⁹ Health Director Staff, Health Protection Agency, Metropolitan Area of Milan, Milan, Italy.
¹⁰ SC Chemical-Clinical Analysis and Microbiology Laboratory, ASST Lodi, Lodi, Italy.
¹¹ Department of Emergency and Urgency, ASST Lodi, Lodi, Italy.
¹² SC Infectious and Tropical Diseases, ASST Lodi, Lodi, Italy.
¹³ These authors contributed equally to this work and share last authorship.
¹⁴ The members of the network are listed under Collaborators.

PMID: 37707980
PMCID: PMC10687988
DOI: 10.2807/1560-7917.ES.2023.28.37.2300471

Abstract

In August 2023, six locally acquired dengue virus 1 infections were detected in Lodi province, Lombardy Region, in northern Italy, where the vector Aedes albopictus is present. Four cases were hospitalised, none died. The viruses clustered with Peruvian and Brazilian strains collected between 2021 and 2023. This preliminary report highlights the importance of continued integrated surveillance of imported vector-borne virus infections and the potential for tropical disease outbreaks in highly populated regions of northern Italy where competent vectors are present.

Keywords: Dengue; Italy; autochthonous cases; phylogenetic analysis; serology; virus.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

**Figure**
Phylogenetic tree of dengue virus serotype 1 complete genome sequences, Italy, August 2023 (n = 5 samples from the current outbreak)

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References

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[1] Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, et al. The global distribution and burden of dengue. Nature. 2013;496(7446):504-7. 10.1038/nature12060 - DOI - PMC - PubMed

[2] Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, et al. The global distribution and burden of dengue. Nature. 2013;496(7446):504-7. 10.1038/nature12060 - DOI - PMC - PubMed

[3] Wilder-Smith A, Ooi EE, Horstick O, Wills B. Dengue. Lancet. 2019;393(10169):350-63. 10.1016/S0140-6736(18)32560-1 - DOI - PubMed

[4] Wilder-Smith A, Ooi EE, Horstick O, Wills B. Dengue. Lancet. 2019;393(10169):350-63. 10.1016/S0140-6736(18)32560-1 - DOI - PubMed

[5] La Ruche G, Souarès Y, Armengaud A, Peloux-Petiot F, Delaunay P, Desprès P, et al. First two autochthonous dengue virus infections in metropolitan France, September 2010. Euro Surveill. 2010;15(39):19676. 10.2807/ese.15.39.19676-en - DOI - PubMed

[6] La Ruche G, Souarès Y, Armengaud A, Peloux-Petiot F, Delaunay P, Desprès P, et al. First two autochthonous dengue virus infections in metropolitan France, September 2010. Euro Surveill. 2010;15(39):19676. 10.2807/ese.15.39.19676-en - DOI - PubMed

[7] Gjenero-Margan I, Aleraj B, Krajcar D, Lesnikar V, Klobučar A, Pem-Novosel I, et al. Autochthonous dengue fever in Croatia, August-September 2010. Euro Surveill. 2011;16(9):19805. 10.2807/ese.16.09.19805-en - DOI - PubMed

[8] Gjenero-Margan I, Aleraj B, Krajcar D, Lesnikar V, Klobučar A, Pem-Novosel I, et al. Autochthonous dengue fever in Croatia, August-September 2010. Euro Surveill. 2011;16(9):19805. 10.2807/ese.16.09.19805-en - DOI - PubMed

[9] Alves MJ, Fernandes PL, Amaro F, Osório H, Luz T, Parreira P, et al. Clinical presentation and laboratory findings for the first autochthonous cases of dengue fever in Madeira Island, Portugal, October 2012. Euro Surveill. 2013;18(6):20398. 10.2807/ese.18.06.20398-en - DOI - PubMed

[10] Alves MJ, Fernandes PL, Amaro F, Osório H, Luz T, Parreira P, et al. Clinical presentation and laboratory findings for the first autochthonous cases of dengue fever in Madeira Island, Portugal, October 2012. Euro Surveill. 2013;18(6):20398. 10.2807/ese.18.06.20398-en - DOI - PubMed

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Preliminary results on an autochthonous dengue outbreak in Lombardy Region, Italy, August 2023

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Affiliations

Preliminary results on an autochthonous dengue outbreak in Lombardy Region, Italy, August 2023

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Collaborators

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Abstract

Conflict of interest statement

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