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. 1979 May 3;279(5708):43-7.
doi: 10.1038/279043a0.

Expression in Escherichia coli of hepatitis B virus DNA sequences cloned in plasmid pBR322

C J Burrell, P Mackay, P J Greenaway, P H Hofschneider, K Murray

Expression in Escherichia coli of hepatitis B virus DNA sequences cloned in plasmid pBR322

C J Burrell et al. Nature. .

Abstract

Fragments of hepatitis B virus DNA isolated from Dane particles have been inserted into the Escherichia coli plasmid pBR322 and cloned. Cells carrying the hybrid plasmid synthesise antigenic material that reacts specifically with antisera to hepatitis B viral antigens.

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