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Comment
. 2023 Oct;3(10):1183-1184.
doi: 10.1038/s43587-023-00500-3.

Leveraging the secretory machinery to eliminate senescent cells

No authors listed
Comment

Leveraging the secretory machinery to eliminate senescent cells

No authors listed. Nat Aging. 2023 Oct.
No abstract available

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References

    1. Di Micco, R. et al. Cellular senescence in ageing: from mechanisms to therapeutic opportunities. Nat. Rev. Mol. Cell Biol. 22, 75–95 (2021). This review describes current understandings of the implications of cellular senescence in aging. - DOI - PubMed
    1. Childs, B. G. et al. Senescence and apoptosis: dueling or complementary cell fates? EMBO Rep. 15, 1139–1153 (2014). This review discusses the dichotomy between senescence and apoptosis in damaged cells. - DOI - PubMed - PMC
    1. Chaib, S. et al. Cellular senescence and senolytics: the path to the clinic. Nat. Med. 28, 1556–1568 (2022). This review describes many of the currently known senolytic strategies. - DOI - PubMed - PMC
    1. Dörr, J. et al. Synthetic lethal metabolic targeting of cellular senescence in cancer therapy. Nature 501, 421–425 (2013). This article describes the endoplasmic reticulum stress triggered in senescent cells as a result of the SASP. - DOI - PubMed
    1. Narita, M. et al. Spatial coupling of mTOR and autophagy augments secretory phenotypes. Science 332, 966–970 (2011). This article reports that senescent cells require an efficiently assembled complex of organelles for an efficient SASP. - DOI - PubMed - PMC

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