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Comment
. 2023 Oct 1;137(4):e35-e36.
doi: 10.1213/ANE.0000000000006588. Epub 2023 Sep 5.

Blinding in Randomized Controlled Trials of Intrathecal Morphine Administration: Can Patients and Anesthesia Providers Really Be Blinded?

Koichi Yoshinaga  1 , Yasushi Tsujimoto  2 , Eriya Imai  3
Affiliations
Comment

Blinding in Randomized Controlled Trials of Intrathecal Morphine Administration: Can Patients and Anesthesia Providers Really Be Blinded?

Koichi Yoshinaga et al. Anesth Analg. .
No abstract available

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Comment in

  • In Response.
    Bang YJ, Jeong JS. Bang YJ, et al. Anesth Analg. 2023 Oct 1;137(4):e36-e37. doi: 10.1213/ANE.0000000000006589. Epub 2023 Sep 5. Anesth Analg. 2023. PMID: 37712480 No abstract available.

Comment on

References

    1. Bang YJ, Lee EK, Kim CS, et al. The effect of intrathecal morphine on postoperative opioid consumption in patients undergoing abdominal surgery for gynecologic malignancy: a randomized sham-controlled trial. Anesth Analg. 2023;137:525–533.
    1. Webster RK, Bishop F, Collins GS, et al. Measuring the success of blinding in placebo-controlled trials: should we be so quick to dismiss it? J Clin Epidemiol. 2021;135:176–181.
    1. Lin YH, Sahker E, Shinohara K, et al. Assessment of blinding in randomized controlled trials of antidepressants for depressive disorders 2000–2020: a systematic review and meta-analysis. eClinicalMed. 2022;50:101505.
    1. Bailey PL, Rhondeau S, Schafer PG, et al. Dose-response pharmacology of intrathecal morphine in human volunteers. Anesthesiology. 1993;79:49–59.
    1. Wang Y, Guo X, Guo Z, Xu M. Preemptive analgesia with a single low dose of intrathecal morphine in multilevel posterior lumbar interbody fusion surgery: a double-blind, randomized, controlled trial. Spine J. 2020;20:989–997.

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