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Meta-Analysis
. 2023 Sep 15;102(37):e34930.
doi: 10.1097/MD.0000000000034930.

Efficacy of acupotomy combined with sodium hyaluronate versus sodium hyaluronate alone in the treatment of knee osteoarthritis: A meta-analysis

Qinglin Wu  1 , Zuqing Wu  2 , Zhifu Lu  2
Affiliations
Meta-Analysis

Efficacy of acupotomy combined with sodium hyaluronate versus sodium hyaluronate alone in the treatment of knee osteoarthritis: A meta-analysis

Qinglin Wu et al. Medicine (Baltimore). .

Abstract

Background: The efficacy of acupotomy combined with hyaluronic sodium acid in the treatment of knee osteoarthritis (KOA) is unclear. Therefore, this meta-analysis aims to evaluate the efficacy of acupotomy combined with hyaluronic sodium acid compared with hyaluronic sodium acid alone in the treatment of KOA.

Methods: Studies from 8 Online databases were searched on KOA treatment using acupotomy combined with sodium hyaluronate until May 2022. The primary outcome indicator was clinical effectiveness, and the secondary outcome indicators included the visual analogue scale scores and Lysholm scores. We calculated the weighted mean difference (WMD) or relative risk for all relevant outcomes.

Results: Nine studies were identified, involving 644 cases. The results showed that acupotomy combined with intra-articular sodium hyaluronate injection for KOA was superior to sodium hyaluronate injection alone in terms of clinical effectiveness (relative risk = 1.17, 95% confidence interval [CI]: 1.09-1.25, P < .001) and visual analogue scale (WMD = -2.1, 95% CI: -2.25 to 1.95, P < .001), Lysholm score (WMD = 13.83, 95% CI: 3.47-24.19, P = .009).

Conclusion: Acupotomy combined with intra-articular sodium hyaluronate injection for KOA is superior to sodium hyaluronate injection alone. Limited by the number and quality of included studies, this conclusion still needs to be verified by more high-quality Research.

Inplasy registration number: INPLASY202350029.

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Conflict of interest statement

The authors have no funding and conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
Literature screening flow chart.
Figure 2.
Figure 2.
Quality assessment of included studies. (A) Summary table of authors’ judgments of risk of bias for each study. (B) Distribution map of authors’ risk judgments for each bias item across studies.
Figure 3.
Figure 3.
Forest diagram of the effective rate of acupotomy combined with sodium hyaluronate in the treatment of knee osteoarthritis.
Figure 4.
Figure 4.
Forest plot of secondary outcome indicators. (A) Forest plot of VAS scores. (B) Forest plot of Lysholm scores. VAS = visual analogue scale.
Figure 5.
Figure 5.
Sensitivity analysis of acupotomy combined with sodium hyaluronate in the treatment of knee osteoarthritis.
Figure 6.
Figure 6.
Funnel plot of the effective rate of acupotomy combined with sodium hyaluronate in the treatment of knee osteoarthritis.
See this image and copyright information in PMC

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