Persistence of ex vivo expanded tumour and pathogen specific T-cells after allogeneic stem cell transplant for myeloid malignancies (the INTACT study)

Wei Jiang^{1

2}, Selmir Avdic^{1

2}, Koon H Lee^{1

2

3}, Janine Street², Gloria Castellano-González², Renee Simms^{1

2}, Leighton E Clancy⁴, Richard Blennerhassett³, Ellis Patrick^{2

5}, Adam S Chan^{5

6}, Helen M McGuire^{6

7}, Nadav Myers², Brian S Gloss², Melissa Gabriel⁸, Caroline M Bateman^{1

2

8}, Ken Micklethwaite^{1

2

3

9}, David J Gottlieb^{1

2

3}, Emily Blyth^{10

11

12}

Affiliations

¹ Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, Australia.
² Westmead Institute for Medical Research, The University of Sydney, Westmead, NSW, Australia.
³ Blood Transplant and Cell Therapies Program, Department of Haematology, Westmead Hospital, Westmead, NSW, Australia.
⁴ Research and Education Network, Western Sydney Area Health Service, Westmead, NSW, Australia.
⁵ School of Mathematics and Statistics, Faculty of Science, University of Sydney, Camperdown, NSW, Australia.
⁶ Charles Perkins Centre, The University of Sydney, Camperdown, NSW, Australia.
⁷ Infection, Immunity and Inflammation Theme, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia.
⁸ Blood Transplant and Cell Therapies Unit, The Children's Hospital at Westmead, Westmead, NSW, Australia.
⁹ Blood Transplant and Cell Therapies Laboratory, Institute for Pathology and Medical Research, NSW Health Pathology, Westmead, NSW, Australia.
¹⁰ Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, Australia. emily.blyth@sydney.edu.au.
¹¹ Westmead Institute for Medical Research, The University of Sydney, Westmead, NSW, Australia. emily.blyth@sydney.edu.au.
¹² Blood Transplant and Cell Therapies Program, Department of Haematology, Westmead Hospital, Westmead, NSW, Australia. emily.blyth@sydney.edu.au.

Wei Jiang et al. Leukemia. 2023 Nov.

. 2023 Nov;37(11):2330-2333.

doi: 10.1038/s41375-023-02033-5. Epub 2023 Sep 15.

¹ Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, Australia.
² Westmead Institute for Medical Research, The University of Sydney, Westmead, NSW, Australia.
³ Blood Transplant and Cell Therapies Program, Department of Haematology, Westmead Hospital, Westmead, NSW, Australia.
⁴ Research and Education Network, Western Sydney Area Health Service, Westmead, NSW, Australia.
⁵ School of Mathematics and Statistics, Faculty of Science, University of Sydney, Camperdown, NSW, Australia.
⁶ Charles Perkins Centre, The University of Sydney, Camperdown, NSW, Australia.
⁷ Infection, Immunity and Inflammation Theme, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia.
⁸ Blood Transplant and Cell Therapies Unit, The Children's Hospital at Westmead, Westmead, NSW, Australia.
⁹ Blood Transplant and Cell Therapies Laboratory, Institute for Pathology and Medical Research, NSW Health Pathology, Westmead, NSW, Australia.
¹⁰ Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, Australia. emily.blyth@sydney.edu.au.
¹¹ Westmead Institute for Medical Research, The University of Sydney, Westmead, NSW, Australia. emily.blyth@sydney.edu.au.
¹² Blood Transplant and Cell Therapies Program, Department of Haematology, Westmead Hospital, Westmead, NSW, Australia. emily.blyth@sydney.edu.au.

No abstract available

References

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1. Qin Y, Zhu H, Jiang B, Li J, Lu X, Li L, et al. Expression patterns of WT1 and PRAME in acute myeloid leukemia patients and their usefulness for monitoring minimal residual disease. Leuk Res. 2009;33:384–90. - DOI - PubMed
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1. Castellano-González G, McGuire HM, Luciani F, Clancy LE, Li Z, Avdic S, et al. Rapidly expanded partially HLA DRB1-matched fungus-specific T cells mediate in vitro and in vivo antifungal activity. Blood Adv. 2020;4:3443–56. - DOI - PubMed - PMC