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Editorial
. 2023 Dec 8;25(12):2237-2238.
doi: 10.1093/neuonc/noad171.

Unraveling schwannomas

Uta E Flucke  1   2 , Laura S Hiemcke-Jiwa  1   3 , Pieter Wesseling  1   4
Affiliations
Editorial

Unraveling schwannomas

Uta E Flucke et al. Neuro Oncol. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

None declared.

Figures

Figure 1.
Figure 1.
Histology of and underlying genetic alterations in schwannomas. The H&E-stained section shows alternating compact (Antoni A, #) and more loosely organized areas (Antoni B, *). Typically, palisading of tumor cell nuclei is seen in the Antoni A component (arrowhead), Verocay bodies representing an “exaggerated” form of such palisading. In the upper part of this figure genes and their protein products are indicated that are already known for some time to play a causal role in the tumorigenesis of schwannomas, all or not in the context of a genetic tumor syndrome. The bottom lists more recently identified (fusion) genes, including the SOX10 indel mutations as reported by Williams et al. The inset shows positivity of the nuclei of schwannoma cells in an immunohistochemical SOX10 staining. Of note, this latter staining does not discriminate between the different genetic drivers underlying the tumorigenesis of schwannomas.
See this image and copyright information in PMC

Comment on

  • Novel SOX10 indel mutations drive schwannomas through impaired transactivation of myelination gene programs.
    Williams EA, Ravindranathan A, Gupta R, Stevers NO, Suwala AK, Hong C, Kim S, Yuan JB, Wu J, Barreto J, Lucas CG, Chan E, Pekmezci M, LeBoit PE, Mully T, Perry A, Bollen A, Van Ziffle J, Devine WP, Reddy AT, Gupta N, Basnet KM, Macaulay RJB, Malafronte P, Lee H, Yong WH, Williams KJ, Juratli TA, Mata DA, Huang RSP, Hiemenz MC, Pavlick DC, Frampton GM, Janovitz T, Ross JS, Chang SM, Berger MS, Jacques L, Song JS, Costello JF, Solomon DA. Williams EA, et al. Neuro Oncol. 2023 Dec 8;25(12):2221-2236. doi: 10.1093/neuonc/noad121. Neuro Oncol. 2023. PMID: 37436963 Free PMC article.

References

    1. Williams EA, Ravindranathan A, Gupta R, et al. . Novel SOX10 indel mutations drive schwannomas through impaired transactivation of myelination gene programs. Neuro-Oncol. 2023;25(12):2221–2236. - PMC - PubMed
    1. Owecki MK. Theodor Schwann (1810-1882). J Neurol. 2021;268(12):4921–4922. - PMC - PubMed
    1. Sonig A, Gandhi V, Nanda A.. From the cell of Schwann to schwannoma—a century’s fruition. World Neurosurg. 2014;82(5):906–911. - PubMed
    1. Verocay J, ed. Zur Kenntnis der “Neurofibrome”. Beitrage Zur Pathologischen Anatomie und zur Allgemeinen Pathologie 1910;48:1–69.
    1. Antoni NRE, ed. Über Rückenmarkstumoren und Neurofibrome: Studien zur Pathologischen Anatomie und Embryogenese: mit einem Klinischen anhang. Bergmann J.F., München - Wiesbaden, 1920.