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. 2023 Sep 16;23(1):468.
doi: 10.1186/s12887-023-04294-6.

Prevalence of markers of beta cell autoimmunity and thyroid disease in children with coeliac disease

Corinne Légeret #  1 , Alexander Kutz #  2   3 , Brunner Jessica  4 , Esther Mundwiler  4 , Henrik Köhler #  5   6 , Luca Bernasconi #  4
Affiliations

Prevalence of markers of beta cell autoimmunity and thyroid disease in children with coeliac disease

Corinne Légeret et al. BMC Pediatr. .

Abstract

Background: Over the last decades, the prevalence of coeliac disease (CD), an autoimmune disorder, rose to 1-2%. Whether patients with CD have higher risk of developing other autoimmune disorders such as type 1 diabetes, Hashimoto thyroiditis, or Graves` disease remains unclear.

Aim: The aim of this study was to determine the prevalence of biomarkers of beta cell and thyroid autoimmunity in children with CD.

Methods: Retrospective cross-sectional cohort study comparing pediatric patients suffering from CD with age and sex-matched healthy controls (HC). Participant`s serum was tested by immunoassay for following autoantibodies (aAb): TSH-receptor antibodies (TRAb), anti-thyroglobulin (anti-Tg), anti-thyroid peroxidase (anti-TPO), anti-glutamic acid decarboxylase (anti-GAD), anti-zinc transporter 8 (anti-ZnT8), anti-islet antigen 2 (anti-IA2) and anti-insulin.

Results: A total of 95 patients with CD (mean age 8.9 years; 63% female) and 199 matched healthy controls (mean age 9.2 years; 59.8% female) were included in the study. For patients with CD, a seroprevalence of 2.1% (vs. 1.5% in HC) was calculated for anti-GAD, 1.1% for anti-IA2 (vs. 1.5% in HC), 3.2% for anti-ZnT8 (vs. 4.2% in HC), and 1.1% (vs. 1% in HC) for anti-insulin. For thyroid disease, a seroprevalence of 2.2% for TRAb (vs. 1% in HC), 0% for anti-TPO (vs. 2.5% in HC) and 4.3% for anti-Tg (vs. 3.5% in HC) was found for patients with CD.

Conclusion: This study suggests a higher prevalence of autoimmune antibodies againstthyroid in children with CD compared to HC, whilst it is similar for pancreatic antibodies. Prospective cohort studies are needed to first evaluate the occurrence of autoimmune antibodies against beta cells and thyroid over a longer follow-up time and second to explore their clinical relevance.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Graphs of auto- antibodies in patients with coeliac disease (CD) and healthy controls
See this image and copyright information in PMC

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References

    1. Popp A, Mäki M. Changing pattern of Childhood Celiac Disease Epidemiology: contributing factors. Front Pediatr. 2019;7:357. doi: 10.3389/fped.2019.00357. - DOI - PMC - PubMed
    1. Parzanese I, Qehajaj D, Grizzi F. Celiac disease: from pathophysiology to treatment. World J Gastrointest Pathophysiol. 2017;8(2):27–38. doi: 10.4291/wjgp.v8.i2.27. - DOI - PMC - PubMed
    1. Pinto-Sanchez MI, Silvester JA, Lebwohl B, et al. Society for the study of Celiac Disease position statement on gaps and opportunities in coeliac disease. Nat Rev Gastroenterol Hepatol. 2021;18:875–84. doi: 10.1038/s41575-021-00511-8. - DOI - PMC - PubMed
    1. Gatti S, Lionetti E, Colombari A, et al. Increased prevalence of Celiac Disease in School-age children in Italy. Clin Gastroenterol Hepatol. 2020;18(3):596–603. doi: 10.1016/j.cgh.2019.06.013. - DOI - PubMed
    1. Zhou C, Gao F, Chen H, et al. Prevalence of coeliac disease in Northwest China: heterogeneity across Northern Silk road ethnic populations. Aliment Pharmacol Ther. 2020;51(11):1116–29. doi: 10.1111/apt.15737. - DOI - PubMed

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