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. 2023 Nov 21;64(6):859-869.
doi: 10.1093/jrr/rrad064.

Proposal of recommended experimental protocols for in vitro and in vivo evaluation methods of boron agents for neutron capture therapy

Yoshihide Hattori  1 , Tooru Andoh  2 , Shinji Kawabata  3 , Naonori Hu  4   5 , Hiroyuki Michiue  6 , Hiroyuki Nakamura  7 , Takahiro Nomoto  8 , Minoru Suzuki  5 , Takushi Takata  5 , Hiroki Tanaka  5 , Tsubasa Watanabe  5 , Koji Ono  4
Affiliations

Proposal of recommended experimental protocols for in vitro and in vivo evaluation methods of boron agents for neutron capture therapy

Yoshihide Hattori et al. J Radiat Res. .

Erratum in

Abstract

Recently, boron neutron capture therapy (BNCT) has been attracting attention as a minimally invasive cancer treatment. In 2020, the accelerator-based BNCT with L-BPA (Borofalan) as its D-sorbitol complex (Steboronine®) for head and neck cancers was approved by Pharmaceutical and Medical Devices Agency for the first time in the world. As accelerator-based neutron generation techniques are being developed in various countries, the development of novel tumor-selective boron agents is becoming increasingly important and desired. The Japanese Society of Neutron Capture Therapy believes it is necessary to propose standard evaluation protocols at each stage in the development of boron agents for BNCT. This review summarizes recommended experimental protocols for in vitro and in vivo evaluation methods of boron agents for BNCT based on our experience with L-BPA approval.

Keywords: in vitro; in vivo; boron agents; boron neutron capture therapy (BNCT); evaluation protocols.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Neutron capture reaction of 10B (left) and a conceptual diagram of cancer cell-selective BNCT (right). Reproduced with permission from JSNCT website (http://www.jsnct.jp/e/about_nct/index.html).
Fig. 2
Fig. 2
Wet-ashing procedure of boron-containing samples using dry block heating system. (a)Wet-ashing sample in centrifuge tube. (b) Dry block heater.
Fig. 3
Fig. 3
An example of sample preparation. (a) TLDs for measurement of gamma ray. (b) Gold foil for measurement of neutron fluence. (c) PTFE table.
See this image and copyright information in PMC

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