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. 1986 Nov;24(5):894-8.
doi: 10.1128/jcm.24.5.894-898.1986.

Effect of age and preexisting antibody on serum antibody response of infants and children to the F and G glycoproteins during respiratory syncytial virus infection

B R Murphy, D W Alling, M H Snyder, E E Walsh, G A Prince, R M Chanock, V G Hemming, W J Rodriguez, H W Kim, B S Graham, et al.

Effect of age and preexisting antibody on serum antibody response of infants and children to the F and G glycoproteins during respiratory syncytial virus infection

B R Murphy et al. J Clin Microbiol. 1986 Nov.

Abstract

The serum antibody response of 50 infants and children infected with respiratory syncytial virus (RSV) was determined by a glycoprotein-specific enzyme-linked immunosorbent assay, and the effects of age and preexisting antibody titer at the time of RSV infection on response to the G and F glycoproteins of RSV were examined. The immune response to the G and F glycoproteins was assessed with anti-human immunoglobulin A to permit measurement of the response of young infants in the presence of maternally derived immunoglobulin G. The findings suggested that age primarily affects the response to the F glycoprotein and that preexisting antibody titer affects the response to the G glycoprotein.

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