. 2024 Feb;83(2):272-276.

doi: 10.1053/j.ajkd.2023.06.008. Epub 2023 Sep 17.

Performance of GFR Estimating Equations in Young Adults

Lesley A Inker¹, Hocine Tighiouart², Ogechi M Adingwupu³, Derek K Ng⁴, Michelle M Estrella⁵, David Maahs⁶, Wei Yang⁷, Marc Froissart⁸, Michael Mauer⁹, Roberto Kalil¹⁰, Vicente Torres¹¹, Martin de Borst¹², Goran Klintmalm¹³, Emilio D Poggio¹⁴, Jesse C Seegmiller¹⁵, Peter Rossing¹⁶, Susan L Furth¹⁷, Bradley A Warady¹⁸, George J Schwartz¹⁹, Ruben Velez²⁰, Josef Coresh⁴, Andrew S Levey³

Affiliations

¹ Department of Medicine, Division of Nephrology, Tufts Medical Center, Boston, Massachusetts. Electronic address: Lesley.Inker@tuftsmedicine.org.
² Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts; Tufts Clinical and Translational Science Institute, Tufts University, Boston, Massachusetts.
³ Department of Medicine, Division of Nephrology, Tufts Medical Center, Boston, Massachusetts.
⁴ Department of Epidemiology, John Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
⁵ Department of Medicine, Division of Nephrology, San Francisco VA Health Care System and University of California, San Francisco, California.
⁶ Division of Endocrinology, Department of Pediatrics, and Stanford Diabetes Research Center, Stanford School of Medicine, Palo Alto, California.
⁷ Departments of Biostatistics, Epidemiology and Informatics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania.
⁸ Clinical Trial Unit, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
⁹ Divisions of Pediatric and Adult Nephrology, University of Minnesota, Minneapolis, Minnesota.
¹⁰ Department of Medicine, Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland.
¹¹ Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.
¹² Faculty of Medical Sciences, University Medical Center Groningen, Groningen, the Netherlands.
¹³ Baylor Simmons Transplant Institute, Dallas, Texas.
¹⁴ Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio.
¹⁵ Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota.
¹⁶ Steno Diabetes Center Copenhagen and the Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
¹⁷ Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, and Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
¹⁸ Division of Pediatric Nephrology, Children's Mercy Kansas City, Kansas City, Missouri.
¹⁹ Department of Pediatrics, Pediatric Nephrology, University of Rochester Medical Center, Rochester, New York.
²⁰ Dallas Nephrology Associates, Dallas, Texas.

PMID: 37717845
PMCID: PMC11080956
DOI: 10.1053/j.ajkd.2023.06.008

Performance of GFR Estimating Equations in Young Adults

Lesley A Inker et al. Am J Kidney Dis. 2024 Feb.

. 2024 Feb;83(2):272-276.

doi: 10.1053/j.ajkd.2023.06.008. Epub 2023 Sep 17.

Authors

Affiliations

¹ Department of Medicine, Division of Nephrology, Tufts Medical Center, Boston, Massachusetts. Electronic address: Lesley.Inker@tuftsmedicine.org.
² Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts; Tufts Clinical and Translational Science Institute, Tufts University, Boston, Massachusetts.
³ Department of Medicine, Division of Nephrology, Tufts Medical Center, Boston, Massachusetts.
⁴ Department of Epidemiology, John Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
⁵ Department of Medicine, Division of Nephrology, San Francisco VA Health Care System and University of California, San Francisco, California.
⁶ Division of Endocrinology, Department of Pediatrics, and Stanford Diabetes Research Center, Stanford School of Medicine, Palo Alto, California.
⁷ Departments of Biostatistics, Epidemiology and Informatics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania.
⁸ Clinical Trial Unit, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
⁹ Divisions of Pediatric and Adult Nephrology, University of Minnesota, Minneapolis, Minnesota.
¹⁰ Department of Medicine, Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland.
¹¹ Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.
¹² Faculty of Medical Sciences, University Medical Center Groningen, Groningen, the Netherlands.
¹³ Baylor Simmons Transplant Institute, Dallas, Texas.
¹⁴ Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio.
¹⁵ Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota.
¹⁶ Steno Diabetes Center Copenhagen and the Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
¹⁷ Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, and Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
¹⁸ Division of Pediatric Nephrology, Children's Mercy Kansas City, Kansas City, Missouri.
¹⁹ Department of Pediatrics, Pediatric Nephrology, University of Rochester Medical Center, Rochester, New York.
²⁰ Dallas Nephrology Associates, Dallas, Texas.

PMID: 37717845
PMCID: PMC11080956
DOI: 10.1053/j.ajkd.2023.06.008

No abstract available

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Figures

**Figure. Difference between eGFR computed using the CKD-EPI and CKiD U25 equations.**
Left panel: Agreement between the CKD-EPI and CKiD U25 equations in the study population. Each grey dot represents a participant. Middle and bottom panels: Comparison of the difference between measured GFR and eGFR creatinine and the average of the two for the CKD-EPI (middle) and CKiD U25 (bottom) equations in the study population. Each grey dot represents a participant. Solid black line is a loess curve. +/−30% and +/−15% lines represent P₃₀ and P₁₅, respectively

See this image and copyright information in PMC

Comment in

EKFC Versus CKD-EPI Equation in Young Adults? No Definitive Answer.
Delanaye P, Pottel H. Delanaye P, et al. Am J Kidney Dis. 2024 Jul;84(1):126. doi: 10.1053/j.ajkd.2024.01.524. Epub 2024 Mar 12. Am J Kidney Dis. 2024. PMID: 38479459 No abstract available.

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References

1. Inker LA, Eneanya ND, Coresh J, et al. New Creatinine- and Cystatin C-Based Equations to Estimate GFR without Race. The New England journal of medicine. 2021;385(19):1737–1749. doi:10.1056/NEJMoa2102953. - DOI - PMC - PubMed
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1. Inker LA, Couture SJ, Tighiouart H, et al. A New Panel Estimated GFR, Including beta2-Microglobulin and beta-Trace Protein and Not Including Race, Developed in a Diverse Population. Am J Kidney Dis. 2021;77(5):673–683. doi:10.1053/j.ajkd.2020.11.005. - DOI - PMC - PubMed
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