Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024;31(27):4267-4285.
doi: 10.2174/0929867331666230915153910.

Small Molecule Inhibitors against the Bacterial Pathogen Brucella

Yingnan Wu  1 , Ye Guo  2 , Yuheng Ma  1 , Hui Yu  3 , Zhanli Wang  4
Affiliations
Review

Small Molecule Inhibitors against the Bacterial Pathogen Brucella

Yingnan Wu et al. Curr Med Chem. 2024.

Abstract

Brucellosis remains one of the major zoonotic diseases worldwide. As a causative agent of brucellosis, it has many ways to evade recognition by the immune system, allowing it to replicate and multiply in the host, causing significant harm to both humans and animals. The pathogenic mechanism of Brucella has not been elucidated, making the identification of drug targets from the pathogenic mechanism a challenge. Metalloenzymatic targets and some protein targets unique to Brucella are exploitable in the development of inhibitors against this disease. The development of specific small molecule inhibitors is urgently needed for brucellosis treatment due to the antibiotic resistance of Brucella. This review summarizes the research on small molecule inhibitors of Brucella, which could be instructive for subsequent studies.

Keywords: Brucella; Brucellosis; drug target; high-throughput screening.; inhibitors; treatment.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Boschiroli M.L.; Foulongne V.; O’Callaghan D.; Brucellosis: A worldwide zoonosis. Curr Opin Microbiol 2001,4(1),58-64 - DOI - PubMed
    1. Kirk M.D.; Pires S.M.; Black R.E.; Caipo M.; Crump J.A.; Devleesschauwer B.; Döpfer D.; Fazil A.; Fischer-Walker C.L.; Hald T.; Hall A.J.; Keddy K.H.; Lake R.J.; Lanata C.F.; Torgerson P.R.; Havelaar A.H.; Angulo F.J.; World Health Organization estimates of the global and regional disease burden of 22 foodborne bacterial, protozoal, and viral diseases, 2010: A data synthesis. PLoS Med 2015,12(12),e1001921 - DOI - PubMed
    1. Atluri V.L.; Xavier M.N.; de Jong M.F.; den Hartigh A.B.; Tsolis R.M.; Interactions of the human pathogenic Brucella species with their hosts. Annu Rev Microbiol 2011,65(1),523-541 - DOI - PubMed
    1. Yu D.; Hui Y.; Zai X.; Xu J.; Liang L.; Wang B.; Yue J.; Li S.; Comparative genomic analysis of Brucella abortus vaccine strain 104M reveals a set of candidate genes associated with its virulence attenuation. Virulence 2015,6(8),745-754 - DOI - PubMed
    1. Jamil T.; Melzer F.; Saqib M.; Shahzad A.; Khan Kasi K.; Hammad Hussain M.; Rashid I.; Tahir U.; Khan I.; Haleem Tayyab M.; Ullah S.; Mohsin M.; Mansoor M.K.; Schwarz S.; Neubauer H.; Serological and molecular detection of bovine brucellosis at institutional livestock farms in Punjab, Pakistan. Int J Environ Res Public Health 2020,17(4),1412 - DOI - PubMed

MeSH terms

Substances