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. 2023 Aug;30(3):283-287.
doi: 10.11005/jbm.2023.30.3.283. Epub 2023 Aug 31.

Black Bone Disease: Ochronotic Arthritis Detected during Knee Arthroplasty

Ho Won Kang  1 , Minsub Kim  1 , Jin-Young Oh  2 , Changhyun Youn  2
Affiliations

Black Bone Disease: Ochronotic Arthritis Detected during Knee Arthroplasty

Ho Won Kang et al. J Bone Metab. 2023 Aug.

Abstract

Alkaptonuria is an extremely rare autosomal recessive metabolic disorder characterized by dark urine, ochronosis, and arthritis of the spine and major joints. We report a case of ochronotic arthritis observed during total knee replacement surgery in a 65-year-old male patient with no relevant medical history. Based on a literature review, this is the first case of ochronotic arthritis reported in Korea.

Keywords: Alkaptonuria; Arthritis; Arthroplasty; Knee; Ochronosis.

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Conflict of interest statement

Conflict of interest

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1
Bluish-black pigmentation on the skin is observed.
Fig. 2
Fig. 2
Arthritic changes in the right knee as observed on the pre-operative radiograph (A) and T2-weighted magnetic resonance image (B).
Fig. 3
Fig. 3
Black discolouration detected in the subchondral bone (A) and cancellous bone (B).
Fig. 4
Fig. 4
Post-operative anteroposterior and lateral radiographs of the right knee.
Fig. 5
Fig. 5
In alkaptonuria, mutations in the gene coding for homogentisic acid dioxygenase cause accumulation of homogentisic acid, leading to pigmentation in the connective tissue.
None
See this image and copyright information in PMC

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