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Review
. 2023 Sep 17;17(2):45-54.
doi: 10.2478/abm-2023-0044. eCollection 2023 Apr.

Polymorphism of fucosyltransferase 3 gene is associated with inflammatory bowel disease: a systematic review

Jiansheng Zheng  1 , Tang Zhu  2
Affiliations
Review

Polymorphism of fucosyltransferase 3 gene is associated with inflammatory bowel disease: a systematic review

Jiansheng Zheng et al. Asian Biomed (Res Rev News). .

Abstract

Background: Inflammatory bowel disease (IBD) is a condition with an unclear genetic basis. Fucosyltransferase 3 (FUT3) could potentially be linked to IBD susceptibility.

Objective: To investigate the association between FUT3 gene polymorphisms and IBD.

Methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 checklist and Population, Intervention, Comparison, Outcomes, and Study (PICOS) guidelines, case-control studies published until April 30, 2020 was searched. Two independent reviewers conducted screening, data extraction, and quality assessment using the Newcastle-Ottawa Scale. Meta-analysis, sensitivity analysis, and Egger tests were performed using RevMan and Stata12.0.

Results: The review included 5 articles and 12 case-control studies involving 1712 IBD patients and 1903 controls. The meta-analysis revealed the following combined odds ratios [95% confidence intervals]: rs3745635 genotype (GA+AA vs GG) 0.84 (0.72-0.97), (GG+GA vs AA) 1.93 (1.23-3.05), (GG vs AA) 2.38 (1.52-3.74), (A vs G) 0.84 (0.73-0.96); rs3894326 genotype (TA+AA vs TT) 1.03 (0.87-1.23), (TT+TA vs AA) 1.19 (0.56-2.51), (TT vs AA) 1.19 (0.56-2.51), (A vs T) 1.02 (0.86-1.20); rs28362459 genotype (TG+GG vs TT) 0.98 (0.85-1.12), (TT+TG vs GG) 1.20 (0.90-1.61), (TT vs GG) 1.21 (0.90-1.62), (G vs T) 0.96 (0.86-1.07). Sensitivity analysis indicated the stability of the results, and Egger analysis showed no significant publication bias.

Conclusions: The rs3745635 gene polymorphism may be associated with IBD susceptibility, whereas the rs3894326 and rs28362459 gene polymorphisms may not be associated with IBD.

Keywords: fucosyltransferase 3 (FUT3); genotype; inflammatory bowel disease (IBD); meta-analysis; polymorphism.

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Figures

Figure 1.
Figure 1.
Study selection flow diagram describing the screening process. FUT3, fucosyltransferase 3 gene; IBD, inflammatory bowel disease.
Figure 2.
Figure 2.
Forest plots of meta-analysis of the genotypes of rs3745635 and IBD. The odds ratios and 95% CIs of the 1712 patients with IBD with GA + AA vs GG rs3745635 genotype and the 1903 controls from 5 articles (A), the 1654 patients with IBD with GG + GA vs AA rs3745635 genotype and the 1843 controls from 4 articles (B), the 1031 patients with IBD with GG vs AA rs3745635 genotype and the 1400 controls from 4 articles (C), and the 3309 patients with IBD with A vs G rs3745635 genotype and the 3684 controls from 4 articles (D) were analyzed by the M–H fixed-effect model. CI, confidence interval; IBD, inflammatory bowel disease; M–H, Mantel–Haenszel.
Figure 3.
Figure 3.
Forest plots of meta-analysis of the genotypes of rs3894326 and IBD. The odds ratios and 95% CIs of 1712 patients with IBD with TA +AA vs TT genotype of the rs3894326 gene and the 1903 controls from 5 articles (A), the 1654 patients with IBD with TT + TA vs AA genotype of the rs3894326 gene and the 1843 controls from 4 articles (B), the 1375 cases of IBD with TT vs AA genotype of the rs3894326 gene and the 1522 controls from 4 articles (C), and the 3309 patients with IBD with A vs T genotype of the rs3894326 gene and the 3684 controls from 4 articles (D) were analyzed by the M–H fixed-effect model. CI, confidence interval; IBD, inflammatory bowel disease; M–H, Mantel–Haenszel.
Figure 4.
Figure 4.
Forest plots of meta-analysis of the genotype of the rs28362459 gene and IBD. The odds ratios and 95% CIs of the 1712 cases of IBD with TG + GG vs TT genotype of the rs28362459 gene and the 1903 controls from 5 articles (A), the 1654 patients with IBD with TT + TG vs GG genotype of the rs28362459 gene and the 1843 controls from 4 articles (B), the 1046 patients with IBD with TT vs GG genotype of the rs28362459 gene and the 1157 controls from 4 articles (C), and the 3309 patients with IBD with G vs T genotype of the rs28362459 gene and the 3684 controls from 4 articles (D) were analyzed by the M–H fixed-effect model. CI, confidence interval; IBD, inflammatory bowel disease; M–H, Mantel–Haenszel.
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