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Case Reports
. 2023 Sep-Oct;79(5):597-600.
doi: 10.1016/j.mjafi.2021.06.022. Epub 2021 Sep 30.

Effects of high bilirubin level in pregnancy in Crigler-Najjar syndrome type 2: An extremely rare but important clinical entity to recognize

Saurabh Bansal  1 , Shubham Jain  1 , Pravin M Rathi  1 , Sanjay Chandnani  1 , Prasanta Debnath  1 , Pankaj Nawghare  1
Affiliations
Case Reports

Effects of high bilirubin level in pregnancy in Crigler-Najjar syndrome type 2: An extremely rare but important clinical entity to recognize

Saurabh Bansal et al. Med J Armed Forces India. 2023 Sep-Oct.

Abstract

Crigler-Najjar is a rare genetic autosomal recessive disorder caused by deficiency of enzyme Uridine 5-Diphosphate Glucuronosyl Transferase (UDP-GT). We report the case of a 24-year-old female with two consecutive pregnancies with a high level of total bilirubin level of 15.1 mg/dl and a direct bilirubin level of 0.8 mg/dl during the first pregnancy. As she was diagnosed case of Crigler Najjar type 2, she was on phenobarbitone 60 mg daily. With careful monitoring, she continued with the same dose. We concluded that even with high bilirubin level (15.1 mg/dl) in pregnancy, no adverse effects to the baby and mother were seen.

Keywords: Crigler–Najjar type 2; Phenobarbitone; Pregnancy.

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Conflict of interest statement

The authors have none to declare.

Figures

Fig. 1
Fig. 1
Pedigree of family with Crigler-Najjar syndrome type II.
Fig. 2
Fig. 2
Relationship of weeks of gestation with bilirubin level.
Fig. 3
Fig. 3
Relationship of age of infant with bilirubin level.
See this image and copyright information in PMC

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