Guidelines for the Prevention and Treatment of Chronic Hepatitis B (version 2022)

Abstract

To facilitate the achieving of the goal of "eliminating viral hepatitis as a major public health threat by 2030" set by the World Health Organization, the Chinese Society of Hepatology together with the Chinese Society of Infectious Diseases (both are branches of the Chinese Medical Association) organized a panel of experts and updated the guidelines for prevention and treatment of chronic hepatitis B in China (version 2022). With the support of available evidence, this revision of the guidelines focuses on active prevention, large scale testing, and expansion of therapeutic indication of chronic hepatitis B with the aim of reducing the hepatitis B related disease burden.

Keywords: Chronic hepatitis B; Guideline; Prevention; Treatment.

Fig. 1. Indications for antiviral therapy of chronic HBV infection.

(a) HBV-related extrahepatic manifestations: glomerulonephritis, vasculitis, etc.; (b) Exclude other causes of ALT elevation: infection with other pathogens, history of taking drugs or poisons, history of alcohol consumption, lipid metabolism disorder, autoimmune disorder, liver congestion or vascular disease, genetic and metabolic liver injury, systemic disease, etc.; (c) NAs: ETV, TDF, TAF or TMF; (d) NAs: ETV, TDF or TAF. HBV, hepatitis B virus; HBsAg, hepatitis B surface antigen; HCC, hepatocellular carcinoma; DAA, direct-acting agents; Nas, nucleoside (acid) analogs; ALT, alanine aminotransferase; ULN, upper limit of normal; Peg-IFN-α, pegylated interferon alpha.