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. 2023 Sep;16(3):162-169.
doi: 10.1177/1753495X221133150. Epub 2022 Oct 19.

Maternal health and pregnancy outcomes in autosomal dominant tubulointerstitial kidney disease

Anthony J Bleyer  1   2 , Kendrah O Kidd  1   2 , Adrienne H Williams  3 , Emily Johnson  4 , Victoria Robins  1 , Lauren Martin  1 , Abbigail Taylor  1 , Alice Kim  1 , Isai Bowline  1 , Dervla M Connaughton  5   6 , Carl D Langefeld  4 , Martina Zivna  2 , Stanislav Kmoch  1   2
Affiliations

Maternal health and pregnancy outcomes in autosomal dominant tubulointerstitial kidney disease

Anthony J Bleyer et al. Obstet Med. 2023 Sep.

Abstract

Introduction: Autosomal dominant tubulointerstitial kidney disease (ADTKD) is an increasingly recognized cause of chronic kidney disease. ADTKD pregnancy outcomes have not previously been described.

Methods: A cross-sectional survey was sent to women from ADTKD families.

Results: Information was obtained from 85 afffected women (164 term pregnancies) and 23 controls (50 pregnancies). Only 16.5% of genetically affected women knew they had ADTKD during pregnancy. Eighteen percent of ADTKD mothers had hypertension during pregnancy versus 12% in controls (p = 0.54) and >40% in comparative studies of chronic kidney disease in pregnancy. Eleven percent of births of ADTKD mothers were <37 weeks versus 0 in controls (p < 0.0001). Cesarean section occurred in 19% of pregnancies in affected women versus 38% of unaffected individuals (p = 0.06). Only 12% of babies required a neonatal intensive care unit stay.

Conclusions: ADTKD pregnancies had lower rates of hypertension during pregnancy versus other forms of chronic kidney disease, which may have contributed to good maternal and fetal outcomes.

Keywords: MUC1; Maternal health; UMOD; autosomal dominant tubulointerstitial kidney disease; epidemiology; pregnancy.

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Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Flow diagram showing different subsets used in the analyses.
Figure 2.
Figure 2.
Estimated glomerular filtration rate (eGFR) values before and after pregnancy for 10 women in whom data was available.
See this image and copyright information in PMC

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