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. 2023 Jan 31;19(1):43-47.
doi: 10.6026/97320630019043. eCollection 2023.

In-vitro anticancer activity of Rauvolfia tetraphylla extract on mcf-7 breast cancer cell lines

Abraham Sabu  1 , Selvaraj J  2 , Gayatridevi R  1 , Dilipan E  1
Affiliations

In-vitro anticancer activity of Rauvolfia tetraphylla extract on mcf-7 breast cancer cell lines

Abraham Sabu et al. Bioinformation. .

Abstract

The medicinal herb Rauwolfia tetraphylla is utilized by South Indian tribes to treat various medical ailments, although its cytotoxicity action has not been studied. As a result, the emphasis of the current investigation is on the anticancer activity of Rauvolfia tetraphylla extracts on MCF-7 breast cancer cell lines, as well as their effects on the levels of gene expression for BCl2 and TGF. The study found that the anticancer activity of R. tetraphylla extract demonstrated significant cytotoxic activity against MCF-7 breast cancer cell lines. Because of this, its anticancer effect may be caused by apoptosis, which is caused by DNA breaking and is helped by active phytochemicals like alkaloids, phenols, and flavonoids in the extracts. It also promotes apoptosis by altering Bcl-2 and TGF expression levels. The present study suggests using R. tetraphylla extract as an anticancer agent in traditional medicine.

Keywords: Rauwolfia tetraphylla; TGF and Bcl1 gene; breast cancer; cytotoxicity; gene expression.

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Figures

Figure 1
Figure 1
Dose dependant cytotoxicity effect of R. tetraphylla over cell viability.
Figure 2
Figure 2
Effect of R. tetraphylla on Bcl-2 mRNA levels on MCF -7 cell lines. Each column represents mean ± SEM compared with control MCF-7 cell lines.
Figure 3
Figure 3
Effect of R. tetraphylla on TGF mRNA levels on MCF -7 cell lines. Each column represents mean ± SEM compared with control MCF-7 cell lines.
See this image and copyright information in PMC

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