Effect of anti-skin disorders of ginsenosides- A Systematic Review

doi:10.1016/j.jgr.2023.04.005

Review

. 2023 Sep;47(5):605-614.

doi: 10.1016/j.jgr.2023.04.005. Epub 2023 May 4.

Effect of anti-skin disorders of ginsenosides- A Systematic Review

Lele Cong¹, Jinli Ma², Yundong Zhang², Yifa Zhou³, Xianling Cong⁴, Miao Hao⁵

Affiliations

¹ Department of Dermatology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
² Key Laboratory of Lymphatic Surgery Jilin Province, Jilin Engineering Laboratory for Lymphatic Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
³ School of Life Sciences, Northeast Normal University, Changchun, Jilin, China.
⁴ Department of Biobank, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
⁵ Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.

PMID: 37720567
PMCID: PMC10499590
DOI: 10.1016/j.jgr.2023.04.005

Review

Effect of anti-skin disorders of ginsenosides- A Systematic Review

Lele Cong et al. J Ginseng Res. 2023 Sep.

. 2023 Sep;47(5):605-614.

doi: 10.1016/j.jgr.2023.04.005. Epub 2023 May 4.

Authors

Lele Cong¹, Jinli Ma², Yundong Zhang², Yifa Zhou³, Xianling Cong⁴, Miao Hao⁵

Affiliations

¹ Department of Dermatology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
² Key Laboratory of Lymphatic Surgery Jilin Province, Jilin Engineering Laboratory for Lymphatic Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
³ School of Life Sciences, Northeast Normal University, Changchun, Jilin, China.
⁴ Department of Biobank, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
⁵ Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.

PMID: 37720567
PMCID: PMC10499590
DOI: 10.1016/j.jgr.2023.04.005

Abstract

Ginsenosides are bioactive components of Panax ginseng with many functions such as anti-aging, anti-oxidation, anti-inflammatory, anti-fatigue, and anti-tumor. Ginsenosides are categorized into dammarane, oleanene, and ocotillol type tricyclic triterpenoids based on the aglycon structure. Based on the sugar moiety linked to C-3, C-20, and C-6, C-20, dammarane type was divided into protopanaxadiol (PPD) and protopanaxatriol (PPT). The effects of ginsenosides on skin disorders are noteworthy. They play anti-aging roles by enhancing immune function, resisting melanin formation, inhibiting oxidation, and elevating the concentration of collagen and hyaluronic acid. Thus, ginsenosides have previously been widely used to resist skin diseases and aging. This review details the role of ginsenosides in the anti-skin aging process from mechanisms and experimental research.

Keywords: anti-skin disorders; ginsenosides; protopanaxadiol type; protopanaxatriols type; skin aging.

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Conflict of interest statement

The author declares no conflicts of interest

Figures

**Fig. 1**
Schematic illustration of plausible biotransformation of PPD.

**Fig. 2**
Schematic illustration of plausible biotransformation of PPT.

**Fig. 3**
The functions of ginsenosides in human epidermal cells.

See this image and copyright information in PMC

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References

1. Grice E.A., Segre J.A. The skin microbiome. Nat Rev Microbiol. 2011 Apr;9(4):244–253. - PMC - PubMed
1. Nybaek H., Jemec G.B. Skin problems in stoma patients. J Eur Acad Dermatol Venereol. 2010 Mar;24(3):249–257. - PubMed
1. Gu Y., Han J., Jiang C., Zhang Y. Biomarkers, oxidative stress and autophagy in skin aging. Ageing Res Rev. 2020 May;59 - PubMed
1. Vaz V.V.A., Jardim da Silva L., Geihs M.A., Maciel F.E., Nery L.E.M., Vargas M.A. Single and repeated low-dose UVB radiation exposures affect the visual system. J Photochem Photobiol B. 2020 Aug;209 - PubMed
1. Pittayapruek P., Meephansan J., Prapapan O., Komine M., Ohtsuki M. Role of matrix metalloproteinases in photoaging and photocarcinogenesis. Int J Mol Sci. 2016 Jun 2;17(6):868. - PMC - PubMed

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[1] Grice E.A., Segre J.A. The skin microbiome. Nat Rev Microbiol. 2011 Apr;9(4):244–253. - PMC - PubMed

[2] Grice E.A., Segre J.A. The skin microbiome. Nat Rev Microbiol. 2011 Apr;9(4):244–253. - PMC - PubMed

[3] Nybaek H., Jemec G.B. Skin problems in stoma patients. J Eur Acad Dermatol Venereol. 2010 Mar;24(3):249–257. - PubMed

[4] Nybaek H., Jemec G.B. Skin problems in stoma patients. J Eur Acad Dermatol Venereol. 2010 Mar;24(3):249–257. - PubMed

[5] Gu Y., Han J., Jiang C., Zhang Y. Biomarkers, oxidative stress and autophagy in skin aging. Ageing Res Rev. 2020 May;59 - PubMed

[6] Gu Y., Han J., Jiang C., Zhang Y. Biomarkers, oxidative stress and autophagy in skin aging. Ageing Res Rev. 2020 May;59 - PubMed

[7] Vaz V.V.A., Jardim da Silva L., Geihs M.A., Maciel F.E., Nery L.E.M., Vargas M.A. Single and repeated low-dose UVB radiation exposures affect the visual system. J Photochem Photobiol B. 2020 Aug;209 - PubMed

[8] Vaz V.V.A., Jardim da Silva L., Geihs M.A., Maciel F.E., Nery L.E.M., Vargas M.A. Single and repeated low-dose UVB radiation exposures affect the visual system. J Photochem Photobiol B. 2020 Aug;209 - PubMed

[9] Pittayapruek P., Meephansan J., Prapapan O., Komine M., Ohtsuki M. Role of matrix metalloproteinases in photoaging and photocarcinogenesis. Int J Mol Sci. 2016 Jun 2;17(6):868. - PMC - PubMed

[10] Pittayapruek P., Meephansan J., Prapapan O., Komine M., Ohtsuki M. Role of matrix metalloproteinases in photoaging and photocarcinogenesis. Int J Mol Sci. 2016 Jun 2;17(6):868. - PMC - PubMed

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Effect of anti-skin disorders of ginsenosides- A Systematic Review

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Effect of anti-skin disorders of ginsenosides- A Systematic Review

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