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. 2023 Jul 27;3(3):e12185.
doi: 10.1002/jcv2.12185. eCollection 2023 Sep.

Relationship between elimination disorders and internalizing-externalizing problems in children: A systematic review and meta-analysis

Claudia Aymerich  1   2   3 , Borja Pedruzo  1 , Malein Pacho  1 , Jon Herrero  1 , María Laborda  1 , Marta Bordenave  1 , Gonzalo Salazar de Pablo  4   5   6 , Eva Sesma  1   2   3   7 , Aranzazu Fernández-Rivas  1   2   3   7 , Ana Catalan  1   2   3   7   8 , Miguel Ángel González-Torres  1   2   3   7
Affiliations

Relationship between elimination disorders and internalizing-externalizing problems in children: A systematic review and meta-analysis

Claudia Aymerich et al. JCPP Adv. .

Abstract

Background: Elimination disorders are highly prevalent in childhood and often associated with clinically relevant comorbid psychological disorders. The aim of this study is to determine if, and to what extent, children with elimination disorders show higher internalizing and externalizing problems than their healthy peers.

Methods: A multistep literature search was performed from database inception until May 1st, 2022. PRISMA/MOOSE-compliant systematic review (PROSPERO: CRD42022303555) were used to identify studies reporting on internalizing and/or externalizing symptoms in children with an elimination disorder and a healthy control (HC) group. First, a systematic review was provided. Second, where data allowed for it, a quantitative meta-analysis with random effects model was conducted to analyze the differences between the elimination disorder and the HC groups for internalizing and externalizing symptoms. Effect size was standardized mean difference. Meta-regression analyses were conducted to examine the effect of sex, age, and study quality. Funnel plots were used to detect a publication bias. Where found, the trim and fill method was used to correct it.

Results: 36 articles were included, 32 of them reporting on enuresis (n = 3244; mean age = 9.4; SD = 3.4; 43.84% female) and 7 of them on encopresis (n = 214; mean age = 8.6; SD = 2.3; 36.24% female). Children with an elimination disorder presented significantly lower self-concept (ES:0.42; 95%CI [0.08; 9.76]; p = 0.017) and higher symptom scores for thought problems (ES:-0.26; 95%CI: -0.43;-0.09]; p = 0.003), externalizing symptoms (ES: -0.20; 95%CI [-0.37;-0.03]; p = 0.020), attention problems (ES:-0.37; 95%CI [-0.51;-0.22]; p = 0.0001), aggressive behavior (ES:-0.33; 95%CI [-0.62;-0.04]; p = 0.025) and social problems (ES:-0.39; 95%CI [-0.58;-0.21]; p = 0.0001). Significant publication biases were found across several of the studied domains. No significant effect of sex, age or quality of the study score was found.

Conclusions: Children with an elimination disorder may have significant internalizing and externalizing problems, as well as impaired self-concept. It is recommendable to screen for them in children with enuresis or encopresis and provide appropriate interventions.

Keywords: comorbidities; elimination disorder; encopresis; enuresis; externalizing; internalizing; self‐concept.

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Conflict of interest statement

The authors have declared that they have no competing or potential conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Forest plots for the standardized mean differences (SMD) of CBCL broad‐band internalizing scale (A) and CBCL broad‐band externalizing scale (B) in children with enuresis versus healthy controls.
FIGURE 2
FIGURE 2
Funnel plots for the CBCL broad‐band internalizing scale meta‐analysis (A) and CBCL broad‐band externalizing scale meta‐analysis (B).
See this image and copyright information in PMC

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