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. 2023 Sep 18;199(14):1495-1500.
doi: 10.1093/rpd/ncac286.

Sex and dose rate effects in automated cytogenetics

Guy Garty  1 , Ekaterina Royba  2 , Mikhail Repin  2 , Igor Shuryak  2 , Naresh Deoli  2 , Razib Obaid  2   3 , Helen C Turner  2 , David J Brenner  2
Affiliations

Sex and dose rate effects in automated cytogenetics

Guy Garty et al. Radiat Prot Dosimetry. .

Abstract

Testing and validation of biodosimetry assays is routinely performed using conventional dose rate irradiation platforms, at a dose rate of approximately 1 Gy/min. In contrast, the exposures from an improvised nuclear device will be delivered over a large range of dose rates with a prompt irradiation component, delivered in less than 1 μs, and a protracted component delivered over hours and days. We present preliminary data from a large demographic study we have undertaken for investigation of age, sex and dose rate effects on dicentric and micronucleus yields. Our data demonstrate reduced dicentric and micronucleus yields at very high dose rates. Additionally, we have seen small differences between males and females, with males having slightly fewer micronuclei and slightly more dicentrics than females, at high doses.

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Figures

Figure 1
Figure 1
Simulated 7–10 fallout dose profile.
Figure 2
Figure 2
Fitted linear dose response for the median-corrected micronucleus index (YMN).
Figure 3
Figure 3
(a) Micronucleus and (b) dicentric yields measured to date, using various dose rates. Data pooled across all donors Data in Supplementary Tables 1 and 2.
Figure 4
Figure 4
Distribution of (a) micronucleus yields and (b) dicentric yields across the samples segregated by sex (shown for a dose rate of 1 Gy/s, similar trends seen for other dose rates). Males are shown on the left, females on the right.
See this image and copyright information in PMC

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