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. 2024 Jan;54(1):e14098.
doi: 10.1111/eci.14098. Epub 2023 Sep 19.

Changing trends in the prevalence of heart failure impairment with Thalassemias over three decades

Hongwei Tang  1 , Nan Zhang  1   2 , Jianchuan Deng  1 , Kang Zhou  1
Affiliations

Changing trends in the prevalence of heart failure impairment with Thalassemias over three decades

Hongwei Tang et al. Eur J Clin Invest. 2024 Jan.

Abstract

Background: To assess the prevalence trend and contributing factors of heart failure (HF) impairment with thalassemias at global, regional and national levels.

Methods: Data on HF impairment with thalassemias was collected from the Global Burden of Disease study. The absolute number and prevalence of the disease were systematically collected for each year, and the estimated annual percentage changes (EAPC) in HF impairment were calculated by gender, region and country to measure temporal trends.

Results: Thalassemias have caused a significant global burden since 1990, and the case number of HF related to thalassemias has been steadily increasing. The highest case number of HF impairments with thalassemias is observed in China (7739 cases) and the highest prevalence is in Pakistan (1.61 per 100,000) currently. Besides, the middle sociodemographic index (SDI) region carries the highest burden of comorbid disease yet exhibits the most evident trend for improvement across the five regions (EAPC = -.98). The burden of thalassemias and comorbid HF is generally higher in males than females with the gender gap growing chasm in the future. Besides, the hotspots of HF impairment with thalassemias have gradually shifted to low SDI regions, though middle SDI regions still hold a relatively higher prevalence (.37 per 100,000) across different regions.

Conclusions: The burden of thalassemias and accompanying HF, as well as their temporal trends, vary greatly across countries and regions. These findings can improve understanding of these conditions and guide policymakers in developing appropriate policies to address disparities between countries.

Keywords: Thalassemias; global burden of diseases; heart failure; prevalence.

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References

REFERENCES

    1. De Simone G, Quattrocchi A, Mancini B, di Masi A, Nervi C, Ascenzi P. Thalassemias: from gene to therapy. Mol Aspects Med. 2022;84:101028.
    1. Meloni A, Pistoia L, Positano V, et al. Increased myocardial extracellular volume is associated with myocardial iron overload and heart failure in thalassemia major. Eur Radiol. 2023;33(2):1266-1276.
    1. Pepe A, Pistoia L, Gamberini MR, et al. National networking in rare diseases and reduction of cardiac burden in thalassemia major. Eur Heart J. 2022;43(26):2482-2492.
    1. Dimitroglou Y, Anagnostopoulos F, Aggeli C, et al. Severity of heart failure and health-related quality of life in beta-thalassemia patients: a cross-sectional study. Ann Hematol. 2020;99(9):2037-2046.
    1. Kremastinos DT, Farmakis D, Aessopos A, et al. Beta-thalassemia cardiomyopathy: history, present considerations, and future perspectives. Circ Heart Fail. 2010;3(3):451-458.