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. 2024 May;102(3):e314-e321.
doi: 10.1111/aos.15753. Epub 2023 Sep 19.

Comparability of input parameters in the German Retina.net ROP registry and the EU-ROP registry - An exemplary comparison between 2011 and 2021

K Winter  1 , J M Pfeil  1 , H Engmann  1 , S Aisenbrey  2 , B Lorenz  3 , K Hufendiek  4 , H Breuss  5 , M Khattab  6 , D Süsskind  7 , V Kakkassery  8 , W A Lagrèze  9 , T Barth  10 , R Liegl  11 , M C Bründer  1 , C Skevas  12 , I Goldammer  13 , B Glitz  14 , E Michalewicz  15 , T U Krohne  16 , I R Bartmann  17 , A Stahl  1 ; Retina.net ROP and EU‐ROP registry study groups
Affiliations
Free article

Comparability of input parameters in the German Retina.net ROP registry and the EU-ROP registry - An exemplary comparison between 2011 and 2021

K Winter et al. Acta Ophthalmol. 2024 May.
Free article

Abstract

Purpose: The German Retina.net ROP registry and its Europe-wide successor, the EU-ROP registry, collect data from patients treated for ROP. This analysis compares input parameters of these two registries to establish a procedure for joint analyses of different registry data using exemplary datasets from the two registries.

Methods: Exemplary datasets from the two databases over a 1-year period each (German Retina.net ROP Registry, 2011, 22 infants; EU-ROP Registry, 2021, 44 infants) were compared. The parameters documented in the two databases were aligned and analysed regarding demographic parameters, treatment modalities, complications within first 24 h and retreatments.

Results: The current analysis showed that data can be aligned for joint analyses with some adjustments within the data structure. The registry with more detailed data collection (EU-ROP) needs to be reduced regarding granularity in order to align the different registries, as the registry with lower granularity determines the level of analyses that can be performed in a comparative approach. In the exemplary datasets, we observed that the overall most common ROP severity in both registries was zone II, 3+ (2011: 70.5%; 2021: 65%), with decreasing numbers of clock hours showing preretinal neovascularisations (2011: 10-12 clock hours in 29% of cases, 2021: 4-6 clock hours in 38%). The most prevalent treatment method was laser coagulation in 2011 (75%) and anti-VEGF therapy in 2021 (86.1%). Within the anti-VEGF group, all patients were treated with bevacizumab in 2011 and with ranibizumab in 2021. Retreatment rates were comparable in 2011 and 2021.

Conclusion: Data from two different ROP registries can be aligned and jointly analysed. The analysis reveals a paradigm shift in treatment modalities, from predominantly laser to anti-VEGF, and within the anti-VEGF group from bevacizumab to ranibizumab in Germany. In addition, there was a trend towards earlier treatment in 2021.

Keywords: ROP; anti‐VEGF; laser coagulation; observational study; registry; retinopathy of prematurity.

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References

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