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Review
. 2023 Sep;16(9):e014742.
doi: 10.1161/CIRCIMAGING.123.014742. Epub 2023 Sep 19.

Cardiovascular Molecular Imaging With Fluorine-19 MRI: The Road to the Clinic

Affiliations
Review

Cardiovascular Molecular Imaging With Fluorine-19 MRI: The Road to the Clinic

Ruud B van Heeswijk et al. Circ Cardiovasc Imaging. 2023 Sep.

Abstract

Fluorine-19 (19F) magnetic resonance imaging is a unique quantitative molecular imaging modality that makes use of an injectable fluorine-containing tracer that generates the only visible 19F signal in the body. This hot spot imaging technique has recently been used to characterize a wide array of cardiovascular diseases and seen a broad range of technical improvements. Concurrently, its potential to be translated to the clinical setting is being explored. This review provides an overview of this emerging field and demonstrates its diagnostic potential, which shows promise for clinical translation. We will describe 19F magnetic resonance imaging hardware, pulse sequences, and tracers, followed by an overview of cardiovascular applications. Finally, the challenges on the road to clinical translation are discussed.

Keywords: cardiovascular disease; cell tracking; fluorine-19; inflammation; magnetic resonance imaging; thrombosis; translational research, biomedical.

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Conflict of interest statement

Disclosures Dr Schwitter receives research support by Bayer Healthcare, Schweiz AG. Dr Schreiber receives research support from Siemens Healthineers. The other authors report no conflicts.

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