Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Sep 19;23(1):497.
doi: 10.1186/s12905-023-02624-5.

Incidence, clinical characteristics, and survival outcomes of ovarian strumal diseases: a retrospective cohort study

Sijian Li #  1 , Ruping Hong #  2 , Min Yin  1   3 , Tianyu Zhang  1 , Xinyue Zhang  1 , Jiaxin Yang  4
Affiliations

Incidence, clinical characteristics, and survival outcomes of ovarian strumal diseases: a retrospective cohort study

Sijian Li et al. BMC Womens Health. .

Abstract

Background: Struma ovarii (SO) is a rare tumor and may transform into ovarian strumal carcinoid (OSC) and/or malignant struma ovarii (MSO), but the incidence, clinical characteristics, and survival outcomes have not been well defined.

Methods: We conducted a retrospective study of patients with ovarian strumal diseases treated in the our hospital between 1980 and 2022. Subgroup analyses of SO, OSC, and MSO were subsequently performed.

Results: A total of 275 cases (2.14%) were identified in a cohort of 12,864 patients with ovarian teratomas, where SO, OSC, and MSO accounted for 83.3%, 12.0%, and 4.7% of cases, respectively. There were no significant differences in age, tumor sizes, elevated tumor markers, and ascites among the three subgroups. At initial treatment, all patients with SO or OSC had FIGO stage I disease except one SO patient presenting metastatic disease, ten patients had MSO confined to the ovary, whereas other three patients had metastatic diseases. Two patients with SO respectively relapsed at peritoneum and anterior mesorectum, while none of the OSC patients presented tumor recurrence or death despite different surgical procedures employed. The 5-year recurrence-free survival rate was 88.9%, and only one death occurred at 9.5 years after diagnosis in patients with MSO. Radioiodine therapy showed satisfactory therapeutic efficacy, but these patients showed poor responses to the chemotherapy.

Conclusion: 2.14% of ovarian teratoma could be classified as SO, of which 12.0% and 4.7% of SO may transform into OSC and MSO, repsectively. The survival outcomes were excellent even after SO transformed into OSC or MSO.

Synopsis: SO occupied 2.14% of ovarian teratoma, where 12.0% and 4.7% of SO may transform into OSC and MSO, respectively, and had excellent survival outcomes.

Keywords: Clinical characteristics; Malignant struma ovarii; Ovarian strumal carcinoid; Struma ovarii; Survival outcomes.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Clinical characteristics, surgical treatment, and clinical outcomes in this cohort. (a) coexisted ipsilateral ovarian tumors in SO; (b) contralateral ovarian tumors in SO; (c) surgery in OSC; (d) surgery in OSC; (e) surgery in MSO; (f) clinical outcomes
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Outwater EK, Siegelman ES, Hunt JL. Ovarian teratomas: tumor types and imaging characteristics. Radiographics. 2001;21(2):475–90. doi: 10.1148/radiographics.21.2.g01mr09475. - DOI - PubMed
    1. Devaney K, Snyder R, Norris HJ, Tavassoli FA. Proliferative and histologically malignant struma ovarii: a clinicopathologic study of 54 cases. Int J Gynecol Pathol. 1993;12(4):333–43. doi: 10.1097/00004347-199310000-00008. - DOI - PubMed
    1. Wang S, He X, Yang H, Chen L. Struma Ovarii Associated with Ascites and elevated CA125: two case reports and review of the literature. Int J Womens Health. 2022;14:1291–6. doi: 10.2147/IJWH.S379128. - DOI - PMC - PubMed
    1. Savelli L, Testa AC, Timmerman D, et al. Imaging of gynecological disease (4): clinical and ultrasound characteristics of struma ovarii. Ultrasound Obstet Gynecol. 2008;32(2):210–9. doi: 10.1002/uog.5396. - DOI - PubMed
    1. Mui MP, Tam KF, Tam FK, Ngan HY. Coexistence of struma ovarii with marked ascites and elevated CA-125 levels: case report and literature review. Arch Gynecol Obstet. 2009;279(5):753–7. doi: 10.1007/s00404-008-0794-1. - DOI - PubMed

Publication types

Substances

Supplementary concepts