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Review
. 2023 Aug 30:17:1253574.
doi: 10.3389/fnins.2023.1253574. eCollection 2023.

Progress on mechanisms of age-related hearing loss

Wen Yang  1 , Xiaolong Zhao  1 , Renjie Chai  2   1   3 , Jiangang Fan  1
Affiliations
Review

Progress on mechanisms of age-related hearing loss

Wen Yang et al. Front Neurosci. .

Abstract

Age-related hearing loss, or presbycusis, is a common cause of hearing loss in elderly people worldwide. It typically presents as progressive, irreversible, and usually affects the high frequencies of hearing, with a tremendous impact on the quality of life. Presbycusis is a complex multidimensional disorder, in addition to aging, multiple factors including exposure to noise, or ototoxic agents, genetic susceptibility, metabolic diseases and lifestyle can influence the onset and severity of presbycusis. With the aging of the body, its ability to clean up deleterious substances produced in the metabolic process is weakened, and the self-protection and repair function of the body is reduced, which in turn leads to irreversible damage to the cochlear tissue, resulting in the occurrence of presbycusis. Presently, oxidative stress (OS), mitochondrial DNA damage, low-grade inflammation, decreased immune function and stem cell depletion have been demonstrated to play a critical role in developing presbycusis. The purpose of this review is to illuminate the various mechanisms underlying this age-related hearing loss, with the goal of advancing our understanding, prevention, and treatment of presbycusis.

Keywords: age-related hearing loss; inflammation; mitochondrial DNA damage; oxidative stress; presbycusis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The pathogenesis and pathological changes of age-related hearing loss (ARHL).
See this image and copyright information in PMC

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