Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2023 Aug 26;11(24):5804-5810.
doi: 10.12998/wjcc.v11.i24.5804.

Malignant form of hidroacanthoma simplex: A case report

Yi-Fei Yang  1 , Rong Wang  1 , Hui Xu  1 , Wei-Guo Long  2 , Xiao-Hui Zhao  2 , Yu-Mei Li  3
Affiliations
Case Reports

Malignant form of hidroacanthoma simplex: A case report

Yi-Fei Yang et al. World J Clin Cases. .

Abstract

Background: This paper presents a case of malignant hidroacanthoma simplex (HAS) and review the literature of previous cases to summarize the histopathological and immunohistochemical features and display the dermoscopic features of malignant HAS.

Case summary: We present an 88-year-old Asian female with malignant HAS. The diagnosis was made according to the histopathological and immunohistochemical results after biopsy. Previous case reports of malignant HAS were retrieved from PubMed to characterize the histopathological and immunohistochemical features. We also display the dermoscopic features of malignant HAS that have not been reported.

Conclusion: Our findings demonstrate that prompt surgical treatment is an effective strategy for malignant HAS. Histopathology and immunohistochemistry are valuable diagnostic tools. This is the first case report to display the dermoscopic features of malignant HAS, and we speculate that dermoscopy may contribute to the diagnosis of malignant HAS.

Keywords: Case report; Dermoscopy; Diagnosis; Histopathology; Immunohistochemistry; Malignant hidroacanthoma simplex.

PubMed Disclaimer

Conflict of interest statement

Conflict-of-interest statement: All the authors declare that they have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Clinical image and dermoscopic examination of the tumour. A: Clinical picture; B and C: Dermoscopic images of the lesion. (B) ×50, (C) ×50.
Figure 2
Figure 2
Histopathological and immunohistochemical analysis. A-C: Haematoxylin and eosin staining of resected specimen (A) ×40, (B) ×200, (C) ×400. A: Blunted epithelial feet (white arrow); B: Neoplastic cells were less stained than the surrounding epithelium (black arrow); C: Dyskeratotic cells (white circle) and mitotic figures (black arrows); D: Immunohistochemical staining showed positivity for CK5/6 (×40); E: EMA (×40); F: CEA was only expressed in ductal structures ×200.
See this image and copyright information in PMC

References

    1. Coburn JG, Smith JL. Hidroacanthoma simplex; an assessment of a selected group of intraepidermal basal cell epitheliomata and of their malignant homologues. Br J Dermatol. 1956;68:400–418. - PubMed
    1. Sun Kim M, Rae Lee H, Lee JH, Son SJ, Song KY. Malignant hidroacanthoma simplex: arising in hidroacanthoma simplex mimicking clonal seborrheic keratosis. Int J Dermatol. 2013;52:258–260. - PubMed
    1. Lee JY, Lin MH. Pigmented malignant hidroacanthoma simplex mimicking irritated seborrheic keratosis. J Cutan Pathol. 2006;33:705–708. - PubMed
    1. Bardach H. Hidroacanthoma simplex with in situ porocarcinoma. A case suggesting malignant transformation. J Cutan Pathol. 1978;5:236–248. - PubMed
    1. Kohli N, Kim SS, Jiang SI. Malignant hidroacanthoma simplex treated with Mohs surgery. Dermatol Surg. 2015;41:518–520. - PubMed

Publication types