Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Feb;28(1):61-68.
doi: 10.1111/1744-9987.14069. Epub 2023 Sep 20.

COVID-19 is more lethal in hemodialysis chronic kidney disease patients with low physical capacity

Rafael B Orcy  1   2 , Caroline C Bluhm  1 , Larissa R Ribeiro  3 , Priscila M Sosa  4 , Bianca D Correa  4 , Franklin C Barcellos  5 , Maristela Böhlke  3   5
Affiliations

COVID-19 is more lethal in hemodialysis chronic kidney disease patients with low physical capacity

Rafael B Orcy et al. Ther Apher Dial. 2024 Feb.

Abstract

Introduction: The mortality rate in patients on maintenance hemodialysis (HD) is high and is associated with low functional capacity (FC). We analyzed the association of FC and COVID-19 lethality among HD patients.

Methods: A cohort study that included evaluations of FC in patients on HD was underway, and the association between FC and lethality was included as an ad-hoc outcome.

Results: One hundred and twelve patients were submitted to a physical, 31 patients contracted symptomatic COVID-19, 20 recovered and 11 died (lethality rate of 35.5%). There was a difference between survivors and non-survivors on six-minutes-walking-test (6MWT) 386.1 ± 112.8 versus 296.9 ± 103.3 meters (p = 0.04), 30 s sit-to-stand test (30CST) score 11.7 ± 3.1 versus 7.7 ± 4.1 (p = 0.006), and timed up and go test (TUG) 9.4 versus 13.6 s (p = 0.009). There was also an association between percentages of predicted 6MWT, 30CST, and TUG with COVID-19 lethality.

Conclusion: Patients on maintenance HD with poorer physical performance presented the worst prognosis from COVID-19 pandemic.

Keywords: COVID-19; functional capacity; hemodialysis patients.

PubMed Disclaimer

References

REFERENCES

    1. Centers for Disease Control and Prevention. COVID-19 people of any age with underlying medical conditions. 2021 Available from: https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/people-...
    1. Tomanoski V, Gjorgjievska G, Nakovska M, Krecova V, Kjamili G, Andonoski A, et al. MO819 risk factors for COVID-19 mortality in hemodialysis patients. Nephrol Dial Transplant. 2021;36(Supplement_1):459-460. https://doi.org/10.1093/ndt/gfab098.0011
    1. Sallis R, Young DR, Tartof SY, Sallis JF, Sall J, Li Q, et al. Physical inactivity is associated with a higher risk for severe COVID-19 outcomes: a study in 48 440 adult patients. Br J Sports Med. 2021;55(19):1099-1105.
    1. Morishita S, Tsubaki A, Shirai N. Physical function was related to mortality in patients with chronic kidney disease and dialysis. Hemodial Int. 2017;21:483-489.
    1. Plantinga LC, Johansen K, Crews DC, Shahinian VB, Robinson BM, Saran R, et al. Association of CKD with disability in the United States. Am J Kidney Dis. 2011;57(2):212-227.

LinkOut - more resources