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Review
. 2023 Aug;19(2):2254262.
doi: 10.1080/21645515.2023.2254262. Epub 2023 Sep 20.

Knowledge mapping of therapeutic cancer vaccine from 2013 to 2022: A bibliometric and visual analysis

Juan Zhao  1 , Bin Liao  1 , Li Gong  1 , Huiyao Yang  1 , Sha Li  1 , Yongsheng Li  1
Affiliations
Review

Knowledge mapping of therapeutic cancer vaccine from 2013 to 2022: A bibliometric and visual analysis

Juan Zhao et al. Hum Vaccin Immunother. 2023 Aug.

Abstract

The investigation of therapeutic cancer vaccines has been ongoing for the past century. Herein, we used VOSviewer and CiteSpace to perform the first global bibliometric analysis of the literature on therapeutic cancer vaccines from 2013 to 2022 aiming to explore the current status and potential research trends. The findings revealed a consistent upward trend in both publication counts and citations. The United States emerged as the leading contributor with the highest number of published papers. Additionally, the analysis of references and keywords indicated that therapeutic cancer vaccines have long been popular topics, whereas neoantigen vaccines, mRNA vaccines, combination strategies, and vaccine delivery systems are emerging research hotspots. This bibliometric study provides a comprehensive and important overview of the current knowledge and potential developments in therapeutic cancer vaccines from 2013 to 2022, which may serve as a valuable reference for scholars interested in further exploring this promising field.

Keywords: Citespace; Therapeutic cancer vaccine; VOSviewer; bibliometric analysis; immunotherapy; knowledge map.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1.
Figure 1.
Step-by-step literature search process.
Figure 2.
Figure 2.
Analyses of literature on therapeutic cancer vaccines published from 2013 to 2022. (a) Annual publication accounts and citation times of publications; (b) Global geographical distribution of publications; (c) The international network cooperation between the countries/regions; (d) Visualization network map of institutions.
Figure 3.
Figure 3.
Visualization map of journals and authors in the field of therapeutic cancer vaccine from 2013 to 2022. (a) The top 10 publishing journals according to number of publications. (b) The top 10 publishing journals according to number of publications. (c) Visualization network map of authors.
Figure 4.
Figure 4.
Visualization map of co-reference analysis in the field of therapeutic cancer vaccine from 2013 to 2022. (a) Network visualization map of the co-citation references; (b) Density map of co-citation reference analysis.
Figure 5.
Figure 5.
The top 25 references with the strongest citation bursts in the co-citation network.
Figure 6.
Figure 6.
Visualization map of keywords analysis in the field of therapeutic cancer vaccine from 2013 to 2022. (a) Density map of keywords based on occurrence frequency; (b) A chronological overview of keywords based on the average publication year; (c) Keyword cluster map based on different research fields.
See this image and copyright information in PMC

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