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Randomized Controlled Trial
. 2023 Sep;72(7):320-321.
doi: 10.12788/jfp.0654.

Is low-dose naltrexone effective in chronic pain management?

Roxanne Radi  1 , Harriet Huang  1 , Jason Rivera  1 , Corey Lyon  1 , Kristen DeSanto  2
Affiliations
Randomized Controlled Trial

Is low-dose naltrexone effective in chronic pain management?

Roxanne Radi et al. J Fam Pract. 2023 Sep.

Abstract

YES. Low-dose naltrexone is as effective as amitriptyline in the treatment of painful diabetic neuropathy and has a superior safety profile (strength of recommendation [SOR], B; single randomized controlled trial [RCT]). Low-dose naltrexone significantly reduced pain by 32% in inflammatory conditions and 44% in neuropathic conditions (SOR, B; single retrospective cohort study). Doses as low as 5.4 mg were found to reduce pain in 95% of patients with fibromyalgia (SOR, B; single prospective dose-response study).

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