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. 2023 Sep 18;69(9):e20230077.
doi: 10.1590/1806-9282.20230077. eCollection 2023.

Serum levels and gestational curve of adiponectin and leptin during adolescent pregnancy

Affiliations

Serum levels and gestational curve of adiponectin and leptin during adolescent pregnancy

Indiomara Baratto et al. Rev Assoc Med Bras (1992). .

Abstract

Objective: This study aimed to develop a curve of weekly serum levels of adiponectin and leptin among pregnant adolescents. In addition, pregestational body mass index and weight gain were assessed and correlated with the serum concentration of these molecules.

Methods: This was a prospective cohort study, including only pregnant adolescents with eutrophic pre-gestational body mass index who were weekly followed during the evolution of gestation. The serum concentrations of adipokines were determined using commercial ELISA kits and were correlated to pre-gestational body mass index and pregnancy weight gain. A total of 157 pregnant women participated in this study.

Results: Adiponectin levels showed a significant decrease among the trimesters (p=0.0004). However, we did not observe significant differences among its levels when compared weekly, neither of which was between adiponectin concentration and pre-gestational body mass index or weight gain (p=0.36 and p=0.10, respectively). In contrast, we detected a significant increase in weekly serum leptin levels (p<0.0001), positively correlated to both pre-gestational body mass index and weight gain (p=0.003 and p=0.0007, respectively).

Conclusion: These adipokines present a different profile throughout adolescent pregnancy.

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Conflict of interest statement

Conflicts of interest: the authors declare there is no conflicts of interest.

Figures

Figure 1.
Figure 1.. Serum adiponectin (A) and leptin (B) levels (ng/mL) during gestational weeks of adolescents.

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