Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2024 Jan;34(1):11-12.
doi: 10.1038/s41422-023-00878-0.

LICOB: a powerful organoid platform for drug discovery

Haojie Jin #  1   2 , Zhen Sun #  3 , René Bernards  4   5
Affiliations
Comment

LICOB: a powerful organoid platform for drug discovery

Haojie Jin et al. Cell Res. 2024 Jan.
No abstract available

PubMed Disclaimer

Figures

Fig. 1
Fig. 1. LICOB establishment and multi-omics analyses of liver cancer organoids.
PLC tissues were collected from patients to generate LICOB. In total, 65 organoids were established from 57 patients, including HCC (n = 44), ICC (n = 12), CHC (n = 4) and HB organoids (n = 5). Multi-omics analyses of these organoids were performed by using reduced representation bisulfite sequencing (RRBS), whole-exome sequencing (WES), RNA-seq, and label-free proteomics. The sensitivity of the organoids to 76 approved or investigational drugs was tested.
See this image and copyright information in PMC

Comment on

  • Pharmaco-proteogenomic characterization of liver cancer organoids for precision oncology.
    Ji S, Feng L, Fu Z, Wu G, Wu Y, Lin Y, Lu D, Song Y, Cui P, Yang Z, Sang C, Song G, Cai S, Li Y, Lin H, Zhang S, Wang X, Qiu S, Zhang X, Hua G, Li J, Zhou J, Dai Z, Wang X, Ding L, Wang P, Gao D, Zhang B, Rodriguez H, Fan J, Clevers H, Zhou H, Sun Y, Gao Q. Ji S, et al. Sci Transl Med. 2023 Jul 26;15(706):eadg3358. doi: 10.1126/scitranslmed.adg3358. Epub 2023 Jul 26. Sci Transl Med. 2023. PMID: 37494474 Free PMC article.

References

    1. Sung H, et al. CA Cancer J. Clin. 2021;71:209–249. doi: 10.3322/caac.21660. - DOI - PubMed
    1. Ji S, et al. Sci. Transl. Med. 2023;15:eadg3358. doi: 10.1126/scitranslmed.adg3358. - DOI - PMC - PubMed
    1. Lancaster MA, et al. Science. 2014;345:1247125. doi: 10.1126/science.1247125. - DOI - PubMed
    1. Crucitta S, et al. Cancer Treat. Rev. 2022;104:102340. doi: 10.1016/j.ctrv.2022.102340. - DOI - PubMed
    1. Gao Q, et al. Cell. 2019;179:561–577. doi: 10.1016/j.cell.2019.08.052. - DOI - PubMed

LinkOut - more resources