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Editorial
. 2024 Mar 1;109(3):709-711.
doi: 10.3324/haematol.2023.283799.

Prehistory of chronic lymphocytic leukemia: clues from the B-cell receptor

Frederic Davi  1
Affiliations
Editorial

Prehistory of chronic lymphocytic leukemia: clues from the B-cell receptor

Frederic Davi. Haematologica. .
No abstract available

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Figures

Figure 1.
Figure 1.
A model of the hypothesized chronic lymphocytic leukemia ontogeny. The initial hit may occur in a hematopoietic stem cell which promotes the production of polyclonal B cells bearing the founder mutation. B-cell receptor (BCR) stimulation by autonomous signaling and possibly by self or foreign antigens leads to oligoclonal low-count monoclonal B-cell lymphocytosis. Further BCR stimulation, as well as the acquisition of genetic lesions, drive gradual selection and clonal expansion of high-count monoclonal B-cell lymphocytosis, which ultimately progresses to overt chronic lymphocytic leukemia. HSC: hematopoietic stem cell; CLL: chronic lymphocytic leukemia; LC-MBL: low-count monoclonal B-cell lymphocytosis; HC-MBL: high-count monoclonal B-cell lymphocytosis.
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References

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