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Review
. 2023 Sep 4:14:1191058.
doi: 10.3389/fphys.2023.1191058. eCollection 2023.

Mechanism, prevention and treatment of cognitive impairment caused by high altitude exposure

Xin Chen #  1 , Jiexin Zhang #  1   2 , Yuan Lin #  3 , Yan Li  4 , Han Wang  5 , Zhanhao Wang  1 , Huawei Liu  1 , Yonghe Hu  6 , Lei Liu  7
Affiliations
Review

Mechanism, prevention and treatment of cognitive impairment caused by high altitude exposure

Xin Chen et al. Front Physiol. .

Abstract

Hypobaric hypoxia (HH) characteristics induce impaired cognitive function, reduced concentration, and memory. In recent years, an increasing number of people have migrated to high-altitude areas for work and study. Headache, sleep disturbance, and cognitive impairment from HH, severely challenges the physical and mental health and affects their quality of life and work efficiency. This review summarizes the manifestations, mechanisms, and preventive and therapeutic methods of HH environment affecting cognitive function and provides theoretical references for exploring and treating high altitude-induced cognitive impairment.

Keywords: cognitive function; hypobaric hypoxia; mechanism; prevention; therapy.

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Conflict of interest statement

Author YuL was employed by Sichuan Xincheng Biological Co., LTD. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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