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. 2023 Sep 16;11(26):6122-6131.
doi: 10.12998/wjcc.v11.i26.6122.

Risk factors for stroke recurrence in young patients with first-ever ischemic stroke: A meta-analysis

Yu Xia  1 , Han Liu  2 , Rui Zhu  3
Affiliations

Risk factors for stroke recurrence in young patients with first-ever ischemic stroke: A meta-analysis

Yu Xia et al. World J Clin Cases. .

Abstract

Background: At present, the incidence rate of ischemic stroke in young people is increasing yearly, and the age of onset is increasingly young. Therefore, primary and secondary prevention of ischemic stroke in young people, especially secondary prevention, is particularly crucial.

Aim: We aimed to comprehensively evaluate risk factors for stroke recurrence in first-ever young ischemic stroke (YIS) patients.

Methods: The meta-analysis was used to quantitatively analyze the research results on risk factors for stroke recurrence in first-ever YIS patients both domestically and internationally. Stata12.0 software was used for heterogeneity testing, publication bias analysis, sensitivity analysis, and the calculation of combined odds ratios and 95% confidence intervals.

Results: The odds ratio (OR) values of the relationship between hypertension and hyperlipidemia and recurrence of first-ever YIS were 1.54 (1.05-2.26) and 1.12 (1.00-1.25), respectively. The OR values of male sex, type 2 diabetes, smoking, drinking and YIS recurrence were 1.66 (0.98-2.79), 1.01 (0.64-1.59), 1.21 (0.83-1.76), and 1.28 (0.82-2.53), respectively. The relationship between male sex, type 2 diabetes, smoking, drinking and YIS recurrence was ambiguous.

Conclusion: Hypertension and hyperlipidemia are important risk factors for stroke recurrence in first-ever YIS patients, and active intervention should be taken.

Keywords: First-ever; Meta-analysis; Recurrence; Risk factors; Young ischemic stroke.

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Conflict of interest statement

Conflict-of-interest statement: We declare that that there is no conflict of interest to disclose.

Figures

Figure 1
Figure 1
Flow chart showing the search strategy. OR: Odds ratio RR: Relative risk.
Figure 2
Figure 2
Forest map. A: The impact of hypertension on stroke recurrence in young ischemic stroke (YIS) patients; B: The impact of hyperlipidemia on stroke recurrence in YIS patients.
Figure 3
Figure 3
Funnel plot. A: The relationship between hypertension and recurrence of young ischemic stroke (YIS); B: The relationship between type 2 diabetes and YIS stroke recurrence.
Figure 4
Figure 4
Sensitivity analysis of the relationship between hypertension and young ischemic stroke recurrence.
See this image and copyright information in PMC

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