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. 2023 Aug 17;19(5):1589-1592.
doi: 10.5114/aoms/169476. eCollection 2023.

A mild type of Nasu-Hakola disease - a case of a woman with presenile dementia and cystic bone lesions

Olga Grodzka  1 , Agnieszka Andrzejczak-Sobocińska  2   3 , Grzegorz Procyk  4   5 , Gabriel Majewski  1 , Stanisław Słyk  1   5 , Rafał Motyl  6 , Izabela Domitrz  1
Affiliations

A mild type of Nasu-Hakola disease - a case of a woman with presenile dementia and cystic bone lesions

Olga Grodzka et al. Arch Med Sci. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The comparison of non-contrast fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) images from (i) December 2019 (left column) and (ii) April 2021 (right column). The images present a progression of cortical and subcortical diffuse lesions of white matter (more visible in the right hemisphere), periventricular atrophy, and gliosis. The image corresponds to diffuse leukoencephalopathy with secondary ventricular widening
Figure 2
Figure 2
Bone cysts visible on the X-ray (arrows). The upper images are anteroposterior projections, and the lower images are lateral projections. A – Radiographs of the right and left wrist. B – Radiographs of the right and left hand. C – Radiographs of the right and left foot
See this image and copyright information in PMC

References

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    1. Tanaka J. Nasu-Hakola disease: a review of its leukoencephalopathic and membranolipodystrophic features. Neuropathology 2000; 20 Suppl: S25-9. - PubMed
    1. Hakola HP. Neuropsychiatric and genetic aspects of a new hereditary disease characterized by progressive dementia and lipomembranous polycystic osteodysplasia. Acta Psychiatr Scand Suppl 1972; 232: 1-173. - PubMed
    1. Krishnadas NC, Abdulla MC, Pachat D. Nasu-Hakola disease – a rare type of presenile dementia. Ann Indian Acad Neurol 2022; 25: 771-2. - PMC - PubMed
    1. Paloneva J, Autti T, Hakola P, Haltia MJ. Polycystic Lipomembranous Osteodysplasia with Sclerosing Leukoencephalopathy. In: GeneReviews(®). Adam MP (eds). University of Washington, Seattle: 1993.