Reply: Soluble oligomers or insoluble fibrils?

Anastasie Mate de Gerando^{1

2}, Noe Quittot^{1

2}, Matthew P Frosch^{1

2}, Bradley T Hyman^{3

4}

Affiliations

¹ Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
² Harvard Medical School, Cambridge, MA, USA.
³ Department of Neurology, Massachusetts General Hospital, Boston, MA, USA. bhyman@mgh.harvard.edu.
⁴ Harvard Medical School, Cambridge, MA, USA. bhyman@mgh.harvard.edu.

Comment

Anastasie Mate de Gerando et al. Acta Neuropathol. 2023 Dec.

. 2023 Dec;146(6):863-866.

doi: 10.1007/s00401-023-02634-5. Epub 2023 Sep 21.

Anastasie Mate de Gerando^{1

2}, Noe Quittot^{1

2}, Matthew P Frosch^{1

2}, Bradley T Hyman^{3

4}

¹ Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
² Harvard Medical School, Cambridge, MA, USA.
³ Department of Neurology, Massachusetts General Hospital, Boston, MA, USA. bhyman@mgh.harvard.edu.
⁴ Harvard Medical School, Cambridge, MA, USA. bhyman@mgh.harvard.edu.

No abstract available

Comment on

Soluble oligomers or insoluble fibrils? Scientific commentary on "Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau".
Stern AM, Selkoe DJ. Stern AM, et al. Acta Neuropathol. 2023 Dec;146(6):861-862. doi: 10.1007/s00401-023-02633-6. Epub 2023 Sep 21. Acta Neuropathol. 2023. PMID: 37733037 No abstract available.

1. Busche MA, Wegmann S, Dujardin S, Commins C, Schiantarelli J, Klickstein N, Kamath TV, Carlson GA, Nelken I, Hyman BT. Tau impairs neural circuits, dominating amyloid-beta effects, in Alzheimer models in vivo. Nat Neurosci. 2019;22:57–64. doi: 10.1038/s41593-018-0289-8. - DOI - PMC - PubMed
1. Colom-Cadena M, Davies C, Sirisi S, Lee JE, Simzer EM, Tzioras M, Querol-Vilaseca M, Sanchez-Aced E, Chang YY, Holt K, et al. Synaptic oligomeric tau in Alzheimer's disease—a potential culprit in the spread of tau pathology through the brain. Neuron. 2023;111:2170–2183 e2176. doi: 10.1016/j.neuron.2023.04.020. - DOI - PubMed
1. DeVos SL, Corjuc BT, Oakley DH, Nobuhara CK, Bannon RN, Chase A, Commins C, Gonzalez JA, Dooley PM, Frosch MP, et al. Synaptic Tau seeding precedes tau pathology in human Alzheimer's disease brain. Front Neurosci. 2018;12:267. doi: 10.3389/fnins.2018.00267. - DOI - PMC - PubMed
1. Dimou E, Katsinelos T, Meisl G, Tuck BJ, Keeling S, Smith AE, Hidari E, Lam JYL, Burke M, Lovestam S, et al. Super-resolution imaging unveils the self-replication of tau aggregates upon seeding. Cell Rep. 2023;42:112725. doi: 10.1016/j.celrep.2023.112725. - DOI - PMC - PubMed
1. Dujardin S, Commins C, Lathuiliere A, Beerepoot P, Fernandes AR, Kamath TV, De Los Santos MB, Klickstein N, Corjuc DL, Corjuc BT, et al. Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease. Nat Med. 2020;26:1256–1263. doi: 10.1038/s41591-020-0938-9. - DOI - PMC - PubMed