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. 2023 Sep 21;13(1):15753.
doi: 10.1038/s41598-023-43045-6.

Synthesis of pyridone derivatives using 2D rod like bifunctional Fe based MOF and CuO nanocomposites as a novel heterogeneous catalyst

Negar Hoot  1 , Enayatollah Sheikhhosseini  2 , Sayed Ali Ahmadi  1 , Mahdieh Ghazizadeh  1 , Moslem Malekshahi  1   3 , Mahdieh Yahyazadehfar  1
Affiliations

Synthesis of pyridone derivatives using 2D rod like bifunctional Fe based MOF and CuO nanocomposites as a novel heterogeneous catalyst

Negar Hoot et al. Sci Rep. .

Abstract

In this study, a new and efficient Rod-like bifunctional Fe-based MOF@CuO nanocomposites (RL BF Fe-based MOF@CuO NC) were synthesized as new and efficient heterogeneous catalyst through a simple method from easily available 1,3,5-benzenetricarbocylic acid linker, nitrate ferric as a source of iron and copper oxide (CuO) nanoparticles under microwave irradiation. The synthesized nanocatalysts were characterized with different techniques such as Brunauer-Emmett-Teller (BET), energy dispersive spectroscopy (EDS), field emission scanning electron microscopy (FE-SEM), mapping, transmission electron microscopy (TEM), X-ray diffraction (XRD), vibrating sample magnetometer (VSM), thermogravimetric analysis (TGA) and Fourier transform infrared spectroscopy (FT-IR). The RL BF Fe-based MOF@CuO NC had relatively high specific surface area (203 m2 g-1) while exhibiting superparamagnetic properties. The catalytic activity of RL BF Fe-based MOF@CuO NC was explored in a facile and green methodology to prepare diverse N‑amino-2-pyridones by one-pot four component reactions comprising aromatic aldehyde, malononitrile, methyl cyanoacetate and hydrazine hydrate within mild and solvent-free conditions. This protocol enjoys features like providing the final products during low reaction times in excellent yields under solvent-free conditions. The use of easily available and inexpensive reactants for the synthesis of the catalyst, environmental compatibility, low catalyst loading, fast and clean work-up and reusability of catalyst for several cycles with consistent activity are counted as the outstanding features of this procedure.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
XRD pattern of RL BF Fe-based MOF@CuO NC.
Figure 2
Figure 2
(a) SEM image and (b) high-resolution SEM image of RL BF Fe-based MOF@CuO NC.
Figure 3
Figure 3
TEM image of RL BF Fe-based MOF@CuO NC.
Figure 4
Figure 4
EDX spectra of RL BF Fe-based MOF@CuO NC.
Figure 5
Figure 5
(a) N2 adsorption–desorption isotherms RL BF Fe-based MOF@CuO NC and (b) BJH results obtained for RL BF Fe-based MOF@CuO NC.
Figure 6
Figure 6
VSM magnetization curves of RL BF Fe-based MOF@CuO NC.
Figure 7
Figure 7
IR (KBr, υ cm−1) curve of (a) CuO, (b) 1,3,5-benzenetricarboxylic acid linker, (c) synthesized Fe-based MOF and (d) RL BF Fe-based MOF@CuO NC.
Figure 8
Figure 8
Four-component synthesis of N‑amino-2-pyridones catalyzed by RL BF Fe-based MOF@CuO NC under solvent-free and reflux conditions.
Figure 9
Figure 9
Reusability of the RL BF Fe-based MOF@CuO NC in the synthesis of 5a.
Figure 10
Figure 10
SEM images of recovered RL BF Fe-based MOF@CuO NC.
Figure 11
Figure 11
XRD Pattern of recovered RL BF Fe-based MOF@CuO NC.
Figure 12
Figure 12
Proposed mechanism for the synthesis of N‑amino-2-pyridones.
See this image and copyright information in PMC

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