Comment on

• EP2 and EP4 receptors regulate aromatase expression in human adipocytes and breast cancer cells. Evidence of a BRCA1 and p300 exchange.

  Subbaramaiah K, Hudis C, Chang SH, Hla T, Dannenberg AJ. Subbaramaiah K, et al. J Biol Chem. 2008 Feb 8;283(6):3433-3444. doi: 10.1074/jbc.M705409200. Epub 2007 Dec 14. J Biol Chem. 2008. Retraction in: J Biol Chem. 2020 Jan 3;295(1):295. doi: 10.1074/jbc.W119.012140. PMID: 18083712 Retracted.
• Heat shock protein 90 inhibitors suppress aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and DNA adduct formation.

  Hughes D, Guttenplan JB, Marcus CB, Subbaramaiah K, Dannenberg AJ. Hughes D, et al. Cancer Prev Res (Phila). 2008 Nov;1(6):485-93. doi: 10.1158/1940-6207.CAPR-08-0149. Cancer Prev Res (Phila). 2008. Retraction in: Cancer Prev Res (Phila). 2022 Jun 2;15(6):415. doi: 10.1158/1940-6207.CAPR-22-0200. PMID: 19138996 Free PMC article. Retracted.
• HDAC6 modulates Hsp90 chaperone activity and regulates activation of aryl hydrocarbon receptor signaling.

  Kekatpure VD, Dannenberg AJ, Subbaramaiah K. Kekatpure VD, et al. J Biol Chem. 2009 Mar 20;284(12):7436-45. doi: 10.1074/jbc.M808999200. Epub 2009 Jan 21. J Biol Chem. 2009. Retraction in: J Biol Chem. 2020 Jan 3;295(1):297. doi: 10.1074/jbc.W119.012142. PMID: 19158084 Free PMC article. Retracted.
• Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland.

  Subbaramaiah K, Howe LR, Bhardwaj P, Du B, Gravaghi C, Yantiss RK, Zhou XK, Blaho VA, Hla T, Yang P, Kopelovich L, Hudis CA, Dannenberg AJ. Subbaramaiah K, et al. Cancer Prev Res (Phila). 2011 Mar;4(3):329-46. doi: 10.1158/1940-6207.CAPR-10-0381. Cancer Prev Res (Phila). 2011. Retraction in: Cancer Prev Res (Phila). 2022 Jun 2;15(6):413. doi: 10.1158/1940-6207.CAPR-22-0202. PMID: 21372033 Free PMC article. Retracted.
• Carnosol, a constituent of Zyflamend, inhibits aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and mutagenesis.

  Mohebati A, Guttenplan JB, Kochhar A, Zhao ZL, Kosinska W, Subbaramaiah K, Dannenberg AJ. Mohebati A, et al. Cancer Prev Res (Phila). 2012 Apr;5(4):593-602. doi: 10.1158/1940-6207.CAPR-12-0002. Epub 2012 Feb 28. Cancer Prev Res (Phila). 2012. Retraction in: Cancer Prev Res (Phila). 2022 Jun 2;15(6):412. doi: 10.1158/1940-6207.CAPR-22-0203. PMID: 22374940 Free PMC article. Retracted.
• Increased levels of COX-2 and prostaglandin E2 contribute to elevated aromatase expression in inflamed breast tissue of obese women.

  Subbaramaiah K, Morris PG, Zhou XK, Morrow M, Du B, Giri D, Kopelovich L, Hudis CA, Dannenberg AJ. Subbaramaiah K, et al. Cancer Discov. 2012 Apr;2(4):356-65. doi: 10.1158/2159-8290.CD-11-0241. Epub 2012 Jan 27. Cancer Discov. 2012. Retraction in: Cancer Discov. 2021 May;11(5):1306. doi: 10.1158/2159-8290.CD-21-0224. PMID: 22576212 Free PMC article. Retracted.
• Pioglitazone, a PPARγ agonist, suppresses CYP19 transcription: evidence for involvement of 15-hydroxyprostaglandin dehydrogenase and BRCA1.

  Subbaramaiah K, Howe LR, Zhou XK, Yang P, Hudis CA, Kopelovich L, Dannenberg AJ. Subbaramaiah K, et al. Cancer Prev Res (Phila). 2012 Oct;5(10):1183-94. doi: 10.1158/1940-6207.CAPR-12-0201. Epub 2012 Jul 10. Cancer Prev Res (Phila). 2012. Retraction in: Cancer Prev Res (Phila). 2022 Jun 2;15(6):411. doi: 10.1158/1940-6207.CAPR-22-0204. PMID: 22787115 Free PMC article. Retracted.
• Caloric restriction reverses obesity-induced mammary gland inflammation in mice.

  Bhardwaj P, Du B, Zhou XK, Sue E, Harbus MD, Falcone DJ, Giri D, Hudis CA, Kopelovich L, Subbaramaiah K, Dannenberg AJ. Bhardwaj P, et al. Cancer Prev Res (Phila). 2013 Apr;6(4):282-9. doi: 10.1158/1940-6207.CAPR-12-0467. Epub 2013 Feb 19. Cancer Prev Res (Phila). 2013. Retraction in: Cancer Prev Res (Phila). 2022 Jun 2;15(6):410. doi: 10.1158/1940-6207.CAPR-22-0205. PMID: 23430756 Free PMC article. Retracted.
• p53 protein regulates Hsp90 ATPase activity and thereby Wnt signaling by modulating Aha1 expression.

  Okayama S, Kopelovich L, Balmus G, Weiss RS, Herbert BS, Dannenberg AJ, Subbaramaiah K. Okayama S, et al. J Biol Chem. 2014 Mar 7;289(10):6513-6525. doi: 10.1074/jbc.M113.532523. Epub 2014 Jan 22. J Biol Chem. 2014. Retraction in: J Biol Chem. 2020 Jan 3;295(1):289. doi: 10.1074/jbc.W119.012134. PMID: 24451373 Free PMC article. Retracted.
• p53 modulates Hsp90 ATPase activity and regulates aryl hydrocarbon receptor signaling.

  Kochhar A, Kopelovich L, Sue E, Guttenplan JB, Herbert BS, Dannenberg AJ, Subbaramaiah K. Kochhar A, et al. Cancer Prev Res (Phila). 2014 Jun;7(6):596-606. doi: 10.1158/1940-6207.CAPR-14-0051. Epub 2014 Apr 15. Cancer Prev Res (Phila). 2014. Retraction in: Cancer Prev Res (Phila). 2022 Jun 2;15(6):408. doi: 10.1158/1940-6207.CAPR-22-0207. PMID: 24736433 Free PMC article. Retracted.
• Id1 Deficiency Protects against Tumor Formation in Apc(Min/+) Mice but Not in a Mouse Model of Colitis-Associated Colon Cancer.

  Zhang N, Subbaramaiah K, Yantiss RK, Zhou XK, Chin Y, Benezra R, Dannenberg AJ. Zhang N, et al. Cancer Prev Res (Phila). 2015 Apr;8(4):303-11. doi: 10.1158/1940-6207.CAPR-14-0411. Epub 2015 Jan 26. Cancer Prev Res (Phila). 2015. Retraction in: Cancer Prev Res (Phila). 2022 Jun 2;15(6):407. doi: 10.1158/1940-6207.CAPR-22-0208. PMID: 25623217 Free PMC article. Retracted.
• Hsp90 and PKM2 Drive the Expression of Aromatase in Li-Fraumeni Syndrome Breast Adipose Stromal Cells.

  Subbaramaiah K, Brown KA, Zahid H, Balmus G, Weiss RS, Herbert BS, Dannenberg AJ. Subbaramaiah K, et al. J Biol Chem. 2016 Jul 29;291(31):16011-23. doi: 10.1074/jbc.M115.698902. Epub 2016 Jun 1. J Biol Chem. 2016. Retraction in: J Biol Chem. 2020 Jan 3;295(1):290. doi: 10.1074/jbc.W119.012135. PMID: 27467582 Free PMC article. Retracted.