. 2023 Sep 7:6:100085.

doi: 10.1016/j.sleepx.2023.100085. eCollection 2023 Dec 15.

Effects of smoking on sleep architecture and ventilatory parameters including apneas: Results of the Tab-OSA study

Sibylle Mauries¹, Léa Bertrand¹, Justine Frija-Masson^{2

3}, Hélène Benzaquen³, Sophie Kalamarides⁴, Karine Sauvage¹, Michel Lejoyeux^{1

5}, Marie-Pia d'Ortho^{2

3}, Pierre A Geoffroy^{1

5

2

6

4}

Affiliations

¹ Département de Psychiatrie et d'addictologie, AP-HP, GHU Paris Nord, DMU Neurosciences, Hôpital Bichat - Claude Bernard, 46 rue Henri Huchard, 75018, Paris, France.
² Université de Paris, NeuroDiderot, Inserm, U1141, 48 boulevard Sérurier, 75019, Paris, France.
³ Explorations Fonctionnelles et Centre du Sommeil- Département de Physiologie Clinique, Assistance Publique des Hôpitaux de Paris, GHU Paris Nord, DMU DREAM, Hôpital Bichat, 46 rue Henri Huchard, 75018, Paris, France.
⁴ Département de Psychiatrie et d'addictologie, AP-HP, GHU Paris Nord, DMU Neurosciences, Hôpital Beaujon, 100 boulevard Général Leclerc, 92110, Clichy, France.
⁵ GHU Paris - Psychiatry & Neurosciences, 1 rue Cabanis, 75014, Paris, France.
⁶ CNRS UPR 3212, Institute for Cellular and Integrative Neurosciences, 5 rue Blaise Pascal, 67000, Strasbourg, France.

PMID: 37736106
PMCID: PMC10509708
DOI: 10.1016/j.sleepx.2023.100085

Effects of smoking on sleep architecture and ventilatory parameters including apneas: Results of the Tab-OSA study

Sibylle Mauries et al. Sleep Med X. 2023.

. 2023 Sep 7:6:100085.

doi: 10.1016/j.sleepx.2023.100085. eCollection 2023 Dec 15.

Authors

Affiliations

¹ Département de Psychiatrie et d'addictologie, AP-HP, GHU Paris Nord, DMU Neurosciences, Hôpital Bichat - Claude Bernard, 46 rue Henri Huchard, 75018, Paris, France.
² Université de Paris, NeuroDiderot, Inserm, U1141, 48 boulevard Sérurier, 75019, Paris, France.
³ Explorations Fonctionnelles et Centre du Sommeil- Département de Physiologie Clinique, Assistance Publique des Hôpitaux de Paris, GHU Paris Nord, DMU DREAM, Hôpital Bichat, 46 rue Henri Huchard, 75018, Paris, France.
⁴ Département de Psychiatrie et d'addictologie, AP-HP, GHU Paris Nord, DMU Neurosciences, Hôpital Beaujon, 100 boulevard Général Leclerc, 92110, Clichy, France.
⁵ GHU Paris - Psychiatry & Neurosciences, 1 rue Cabanis, 75014, Paris, France.
⁶ CNRS UPR 3212, Institute for Cellular and Integrative Neurosciences, 5 rue Blaise Pascal, 67000, Strasbourg, France.

PMID: 37736106
PMCID: PMC10509708
DOI: 10.1016/j.sleepx.2023.100085

Abstract

Background: The interaction between smoking and sleep seems appears to be bidirectional, but few studies evaluated the impact of smoking and its cessation on objective sleep parameters. In this context, this new study aimed to assess the impact of smoking and its cessation on sleep architecture and on ventilatory sleep parameters, particularly the presence of sleep apnea syndrome (apnea-hypopnea index (AHI)≥15). Methods: Patients hospitalized for polysomnographic sleep exploration were compared according to their smoking status: active smokers (AS), former smokers (FS), non-smokers (NoNi). Psychiatric and non-psychiatric co-morbidities and treatment or substance use were taken into account in the analyses.

Results: A total of 170 participants were included (N = 37 FS, 39 AS, 86 NoNi). A significant decrease in the mean nocturnal O₂ saturation was observed for FS and AS compared to NoNi. No differences were found regarding AHI. Regarding sleep architecture, we observed a significant decrease in the slow wave sleep duration for AS compared to NoNi, and interestingly not between FS and NoNi.

Conclusion: This study suggests that current smokers suffer from alterations in both sleep architecture and ventilatory parameters, the later appears to persist even after smoking cessation.

Keywords: Obstructive sleep apnea syndrome; Polysomnography; Sleep architecture; Sleep parameters; Smoking; Tobacco.

PubMed Disclaimer

Conflict of interest statement

The manuscript has not been published before, is not being considered for publication elsewhere, and have been approved by each author. We report no financial affiliation or other relationship relevant to the subject matter of this article.

Figures

**Fig. 1**
Flow Chart. *AS = Active smoker; ASV = Adaptative servo-ventilation; CPAP = Continuous Positive Airway Pressure; FS = Former smoker; NoNi = Individuals* without any history of nicotine addiction; PSG = Polysomnography; (n) = excluded individuals.

See this image and copyright information in PMC

Cited by

Smoking History and Nicotine Dependence Alter Sleep Features in Patients with Obstructive Sleep Apnea-Hypopnea Syndrome.
Grigoriou I, Kotoulas SC, Porpodis K, Spyratos D, Papagiouvanni I, Tsantos A, Michailidou A, Mourelatos C, Mouratidou C, Alevroudis I, Tsakiri K, Dourliou V, Sakkou A, Matzolas S, Marneri A, Pataka A. Grigoriou I, et al. Healthcare (Basel). 2024 Dec 30;13(1):49. doi: 10.3390/healthcare13010049. Healthcare (Basel). 2024. PMID: 39791655 Free PMC article.
Increased loop gain and upper airway collapsibility among smoking patients with obstructive sleep apnoea.
Hang LW, Finnsson E, Ágústsson JS, Sands SA, Cheng WJ. Hang LW, et al. ERJ Open Res. 2025 Aug 4;11(4):01283-2024. doi: 10.1183/23120541.01283-2024. eCollection 2025 Jul. ERJ Open Res. 2025. PMID: 40761648 Free PMC article.
Sleep biomarkers of seasonal vulnerability in major depressive episodes: a clinical study using actigraphy and polysomnography.
Maruani J, Vissouze L, Ambar Akkaoui M, Zehani F, Frija J, Lejoyeux M, d'ORTHO MP, Geoffroy PA. Maruani J, et al. Int J Clin Health Psychol. 2025 Apr-Jun;25(2):100595. doi: 10.1016/j.ijchp.2025.100595. Epub 2025 Jun 13. Int J Clin Health Psychol. 2025. PMID: 40583939 Free PMC article.
The Interactions between Smoking and Sleep.
Grigoriou I, Kotoulas SC, Porpodis K, Spyratos D, Papagiouvanni I, Tsantos A, Michailidou A, Mourelatos C, Mouratidou C, Alevroudis I, Marneri A, Pataka A. Grigoriou I, et al. Biomedicines. 2024 Aug 5;12(8):1765. doi: 10.3390/biomedicines12081765. Biomedicines. 2024. PMID: 39200229 Free PMC article. Review.
Abnormal power and spindle wave activity during sleep in young smokers.
Dong Y, Cheng Y, Wang J, Ren Z, Lu Y, Yuan K, Dong F, Yu D. Dong Y, et al. Front Neurosci. 2025 Feb 11;19:1534758. doi: 10.3389/fnins.2025.1534758. eCollection 2025. Front Neurosci. 2025. PMID: 40008299 Free PMC article.

References

1. World Health Organization Tobacco https://www.who.int/news-room/fact-sheets/detail/tobacco
1. Reitsma M.B., Kendrick P.J., Ababneh E., Abbafati C., Abbasi-Kangevari M., Abdoli A., Abedi A., Abhilash E.S., Abila D.B., Aboyans V., Abu-Rmeileh N.M., Adebayo O.M., Advani S.M., Aghaali M., Ahinkorah B.O., Ahmad S., Ahmadi K., Ahmed H., Aji B., Akunna C.J., Al-Aly Z., Alanzi T.M., Alhabib K.F., Ali L., Alif S.M., Alipour V., Aljunid S.M., Alla F., Allebeck P., Alvis-Guzman N., Amin T.T., Amini S., Amu H., Amul G.G.H., Ancuceanu R., Anderson J.A., Ansari-Moghaddam A., Antonio C.A.T., Antony B., Anvari D., Arabloo J., Arian N.D., Arora M., Asaad M., Ausloos M., Awan A.T., Ayano G., Aynalem G.L., Azari S., B D.B., Badiye A.D., Baig A.A., Bakhshaei M.H., Banach M., Banik P.C., Barker-Collo S.L., Bärnighausen T.W., Barqawi H.J., Basu S., Bayati M., Bazargan-Hejazi S., Behzadifar M., Bekuma T.T., Bennett D.A., Bensenor I.M., Berfield K.S.S., Bhagavathula A.S., Bhardwaj N., Bhardwaj P., Bhattacharyya K., Bibi S., Bijani A., Bintoro B.S., Biondi A., Birara S., Braithwaite D., Brenner H., Brunoni A.R., Burkart K., Butt Z.A., Caetano Dos Santos F.L., Cámera L.A., Car J., Cárdenas R., Carreras G., Carrero J.J., Castaldelli-Maia J.M., Cattaruzza M.S.S., Chang J.-C., Chen S., Chu D.-T., Chung S.-C., Cirillo M., Costa V.M., Couto R.A.S., Dadras O., Dai X., Damasceno A.A.M., Damiani G., Dandona L., Dandona R., Daneshpajouhnejad P., Darega Gela J., Davletov K., Derbew Molla M., Dessie G.A., Desta A.A., Dharmaratne S.D., Dianatinasab M., Diaz D., Do H.T., Douiri A., Duncan B.B., Duraes A.R., Eagan A.W., Ebrahimi Kalan M., Edvardsson K., Elbarazi I., El Tantawi M., Esmaeilnejad S., Fadhil I., Faraon E.J.A., Farinha C.S.E.S., Farwati M., Farzadfar F., Fazlzadeh M., Feigin V.L., Feldman R., Fernandez Prendes C., Ferrara P., Filip I., Filippidis F., Fischer F., Flor L.S., Foigt N.A., Folayan M.O., Foroutan M., Gad M.M., Gaidhane A.M., Gallus S., Geberemariyam B.S., Ghafourifard M., Ghajar A., Ghashghaee A., Giampaoli S., Gill P.S., Glozah F.N., Gnedovskaya E.V., Golechha M., Gopalani S.V., Gorini G., Goudarzi H., Goulart A.C., Greaves F., Guha A., Guo Y., Gupta B., Gupta R.D., Gupta R., Gupta T., Gupta V., Hafezi-Nejad N., Haider M.R., Hamadeh R.R., Hankey G.J., Hargono A., Hartono R.K., Hassankhani H., Hay S.I., Heidari G., Herteliu C., Hezam K., Hird T.R., Hole M.K., Holla R., Hosseinzadeh M., Hostiuc S., Househ M., Hsiao T., Huang J., Iannucci V.C., Ibitoye S.E., Idrisov B., Ilesanmi O.S., Ilic I.M., Ilic M.D., Inbaraj L.R., Irvani S.S.N., Islam J.Y., Islam R.M., Islam S.M.S., Islami F., Iso H., Itumalla R., Iwagami M., Jaafari J., Jain V., Jakovljevic M., Jang S.-I., Janjani H., Jayaram S., Jeemon P., Jha R.P., Jonas J.B., Joo T., Jürisson M., Kabir A., Kabir Z., Kalankesh L.R., Kanchan T., Kandel H., Kapoor N., Karimi S.E., Katikireddi S.V., Kebede H.K., Kelkay B., Kennedy R.D., Khoja A.T., Khubchandani J., Kim G.R., Kim Y.-E., Kimokoti R.W., Kivimäki M., Kosen S., Koulmane Laxminarayana S.L., Koyanagi A., Krishan K., Kugbey N., Kumar G.A., Kumar N., Kurmi O.P., Kusuma D., Lacey B., Lam J.O., Landires I., Lasrado S., Lauriola P., Lee D.W., Lee Y.H., Leung J., Li S., Lin H., Linn S., Liu W., Lopez A.D., Lopukhov P.D., Lorkowski S., Lugo A., Majeed A., Maleki A., Malekzadeh R., Malta D.C., Mamun A.A., Manjunatha N., Mansouri B., Mansournia M.A., Martinez-Raga J., Martini S., Mathur M.R., Medina-Solís C.E., Mehata S., Mendoza W., Menezes R.G., Meretoja A., Meretoja T.J., Miazgowski B., Michalek I.M., Miller T.R., Mirrakhimov E.M., Mirzaei H., Mirzaei-Alavijeh M., Misra S., Moghadaszadeh M., Mohammad Y., Mohammadian-Hafshejani A., Mohammed S., Mokdad A.H., Monasta L., Moni M.A., Moradi G., Moradi-Lakeh M., Moradzadeh R., Morrison S.D., Mossie T.B., Mubarik S., Mullany E.C., Murray C.J.L., Naghavi M., Naghshtabrizi B., Nair S., Nalini M., Nangia V., Naqvi A.A., Narasimha Swamy S., Naveed M., Nayak S., Nayak V.C., Nazari J., Nduaguba S.O., Neupane Kandel S., Nguyen C.T., Nguyen H.L.T., Nguyen S.H., Nguyen T.H., Nixon M.R., Nnaji C.A., Norrving B., Noubiap J.J., Nowak C., Ogbo F.A., Oguntade A.S., Oh I.-H., Olagunju A.T., Oren E., Otstavnov N., Otstavnov S.S., Owolabi M.O., P A M., Pakhale S., Pakshir K., Palladino R., Pana A., Panda-Jonas S., Pandey A., Parekh U., Park E.-C., Park E.-K., Pashazadeh Kan F., Patton G.C., Pawar S., Pestell R.G., Pinheiro M., Piradov M.A., Pirouzpanah S., Pokhrel K.N., Polibin R.V., Prashant A., Pribadi D.R.A., Radfar A., Rahimi-Movaghar V., Rahman A., Rahman M.H.U., Rahman M.A., Rahmani A.M., Rajai N., Ram P., Ranabhat C.L., Rathi P., Rawal L., Renzaho A.M.N., Reynales-Shigematsu L.M., Rezapour A., Riahi S.M., Riaz M.A., Roever L., Ronfani L., Roshandel G., Roy A., Roy B., Sacco S., Saddik B., Sahebkar A., Salehi S., Salimzadeh H., Samaei M., Samy A.M., Santos I.S., Santric-Milicevic M.M., Sarrafzadegan N., Sathian B., Sawhney M., Saylan M., Schaub M.P., Schmidt M.I., Schneider I.J.C., Schutte A.E., Schwendicke F., Seidu A.-A., Senthil Kumar N., Sepanlou S.G., Seylani A., Shafaat O., Shah S.M., Shaikh M.A., Shalash A.S., Shannawaz M., Sharafi K., Sheikh A., Sheikhbahaei S., Shigematsu M., Shiri R., Shishani K., Shivakumar K.M., Shivalli S., Shrestha R., Siabani S., Sidemo N.B., Sigfusdottir I.D., Sigurvinsdottir R., Silva D.A.S., Silva J.P., Singh A., Singh J.A., Singh V., Sinha D.N., Sitas F., Skryabin V.Y., Skryabina A.A., Soboka M., Soriano J.B., Soroush A., Soshnikov S., Soyiri I.N., Spurlock E.E., Sreeramareddy C.T., Stein D.J., Steiropoulos P., Stortecky S., Straif K., Suliankatchi Abdulkader R., Sulo G., Sundström J., Tabuchi T., Tadakamadla S.K., Taddele B.W., Tadesse E.G., Tamiru A.T., Tareke M., Tareque M.I., Tarigan I.U., Temsah M.-H., Thankappan K.R., Thapar R., Tichopad A., Tolani M.A., Topouzis F., Tovani-Palone M.R., Tran B.X., Tripathy J.P., Tsegaye G.W., Tsilimparis N., Tymeson H.D., Ullah A., Ullah S., Unim B., Updike R.L., Vacante M., Valdez P.R., Vardavas C., Varona Pérez P., Vasankari T.J., Venketasubramanian N., Verma M., Vetrova M.V., Vo B., Vu G.T., Waheed Y., Wang Y., Welding K., Werdecker A., Whisnant J.L., Wickramasinghe N.D., Yamagishi K., Yandrapalli S., Yatsuya H., Yazdi-Feyzabadi V., Yeshaw Y., Yimmer M.Z., Yonemoto N., Yu C., Yunusa I., Yusefzadeh H., Zahirian Moghadam T., Zaman M.S., Zamanian M., Zandian H., Zar H.J., Zastrozhin M.S., Zastrozhina A., Zavala-Arciniega L., Zhang J., Zhang Z.-J., Zhong C., Zuniga Y.M.H., Gakidou E. Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990–2019: a systematic analysis from the Global Burden of Disease Study 2019. Lancet. 2021;397:2337–2360. doi: 10.1016/S0140-6736(21)01169-7. - DOI - PMC - PubMed
1. Nutt D., King L.A., Saulsbury W., Blakemore C. Development of a rational scale to assess the harm of drugs of potential misuse. Lancet. 2007;369:1047–1053. doi: 10.1016/S0140-6736(07)60464-4. - DOI - PubMed
1. Hogg R.C., Bertrand D. Partial agonists as therapeutic agents at neuronal nicotinic acetylcholine receptors. Biochem Pharmacol. 2007;73:459–468. doi: 10.1016/j.bcp.2006.08.010. - DOI - PubMed
1. Balfour D.J.K. The neurobiology of tobacco dependence: a preclinical perspective on the role of the dopamine projections to the nucleus accumbens [corrected] Nicotine Tob. Res. Off. J. Soc. Res. Nicotine Tob. 2004;6:899–912. doi: 10.1080/14622200412331324965. - DOI - PubMed

LinkOut - more resources

Full Text Sources
Research Materials
- NCI CPTC Antibody Characterization Program

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Effects of smoking on sleep architecture and ventilatory parameters including apneas: Results of the Tab-OSA study

Affiliations

Effects of smoking on sleep architecture and ventilatory parameters including apneas: Results of the Tab-OSA study

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

Similar articles

Cited by

References

LinkOut - more resources

Full Text Sources

Research Materials

Abstract

Conflict of interest statement

Figures

Similar articles

Cited by

References

Related information

LinkOut - more resources

Full Text Sources

Research Materials