Novel Haloacethydrazides as AEP Inhibitors for Treating Alzheimer's Disease

doi:10.1021/acsmedchemlett.3c00367

Editorial

. 2023 Sep 5;14(9):1165-1166.

doi: 10.1021/acsmedchemlett.3c00367. eCollection 2023 Sep 14.

Novel Haloacethydrazides as AEP Inhibitors for Treating Alzheimer's Disease

Ram W Sabnis¹, Anika R Sabnis²

Affiliations

¹ Smith, Gambrell & Russell LLP, 1105 W. Peachtree Street NE, Suite 1000, Atlanta, Georgia 30309, United States.
² Neuroscience Institute, Georgia State University, Atlanta, Georgia 30303, United States.

PMID: 37736172
PMCID: PMC10510664
DOI: 10.1021/acsmedchemlett.3c00367

Editorial

Novel Haloacethydrazides as AEP Inhibitors for Treating Alzheimer's Disease

Ram W Sabnis et al. ACS Med Chem Lett. 2023.

. 2023 Sep 5;14(9):1165-1166.

doi: 10.1021/acsmedchemlett.3c00367. eCollection 2023 Sep 14.

Authors

Ram W Sabnis¹, Anika R Sabnis²

Affiliations

¹ Smith, Gambrell & Russell LLP, 1105 W. Peachtree Street NE, Suite 1000, Atlanta, Georgia 30309, United States.
² Neuroscience Institute, Georgia State University, Atlanta, Georgia 30303, United States.

PMID: 37736172
PMCID: PMC10510664
DOI: 10.1021/acsmedchemlett.3c00367

Abstract

Provided herein are novel haloacethydrazides as AEP inhibitors, pharmaceutical compositions, use of such compounds in treating Alzheimer's disease, and processes for preparing such compounds.

Published 2023 by American Chemical Society.

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Conflict of interest statement

The authors declare no competing financial interest.

Cited by

3-Alkynyl Carboxamides as AEP Modulators for Treating Alzheimer's Disease.
Sabnis RW, Sabnis AR. Sabnis RW, et al. ACS Med Chem Lett. 2024 Jan 4;15(2):159-160. doi: 10.1021/acsmedchemlett.3c00544. eCollection 2024 Feb 8. ACS Med Chem Lett. 2024. PMID: 38352845 Free PMC article.

References

1. Zhou X.; Shi Q.; Zhang X.; Gu L.; Li J.; Quan S.; Zhao X.; Li Q. ApoE4-mediated blood-brain barrier damage in Alzheimer's disease: Progress and prospects. Brain Res. Bull. 2023, 199, 110670.10.1016/j.brainresbull.2023.110670. - DOI - PubMed
1. Susmitha G.; Kumar R. Role of microbial dysbiosis in the pathogenesis of Alzheimer's disease. Neuropharmacology 2023, 229, 109478.10.1016/j.neuropharm.2023.109478. - DOI - PubMed
1. Chu C.; Yu L.; Qi G.; Mi Y.; Wu W.; Lee Y.; Zhai Q.; Tian F.; Chen W. Can dietary patterns prevent cognitive impairment and reduce Alzheimer's disease risk: Exploring the underlying mechanisms of effects. Neurosci. Behav. Rev. 2022, 135, 104556.10.1016/j.neubiorev.2022.104556. - DOI - PubMed
1. Tang T. M. S.; Luk L. Y. P. Asparaginyl endopeptidases: enzymology, applications and limitations. Org. Biomol. Chem. 2021, 19, 5048–5062. 10.1039/D1OB00608H. - DOI - PMC - PubMed

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[1] Zhou X.; Shi Q.; Zhang X.; Gu L.; Li J.; Quan S.; Zhao X.; Li Q. ApoE4-mediated blood-brain barrier damage in Alzheimer's disease: Progress and prospects. Brain Res. Bull. 2023, 199, 110670.10.1016/j.brainresbull.2023.110670. - DOI - PubMed

[2] Zhou X.; Shi Q.; Zhang X.; Gu L.; Li J.; Quan S.; Zhao X.; Li Q. ApoE4-mediated blood-brain barrier damage in Alzheimer's disease: Progress and prospects. Brain Res. Bull. 2023, 199, 110670.10.1016/j.brainresbull.2023.110670. - DOI - PubMed

[3] Susmitha G.; Kumar R. Role of microbial dysbiosis in the pathogenesis of Alzheimer's disease. Neuropharmacology 2023, 229, 109478.10.1016/j.neuropharm.2023.109478. - DOI - PubMed

[4] Susmitha G.; Kumar R. Role of microbial dysbiosis in the pathogenesis of Alzheimer's disease. Neuropharmacology 2023, 229, 109478.10.1016/j.neuropharm.2023.109478. - DOI - PubMed

[5] Chu C.; Yu L.; Qi G.; Mi Y.; Wu W.; Lee Y.; Zhai Q.; Tian F.; Chen W. Can dietary patterns prevent cognitive impairment and reduce Alzheimer's disease risk: Exploring the underlying mechanisms of effects. Neurosci. Behav. Rev. 2022, 135, 104556.10.1016/j.neubiorev.2022.104556. - DOI - PubMed

[6] Chu C.; Yu L.; Qi G.; Mi Y.; Wu W.; Lee Y.; Zhai Q.; Tian F.; Chen W. Can dietary patterns prevent cognitive impairment and reduce Alzheimer's disease risk: Exploring the underlying mechanisms of effects. Neurosci. Behav. Rev. 2022, 135, 104556.10.1016/j.neubiorev.2022.104556. - DOI - PubMed

[7] Tang T. M. S.; Luk L. Y. P. Asparaginyl endopeptidases: enzymology, applications and limitations. Org. Biomol. Chem. 2021, 19, 5048–5062. 10.1039/D1OB00608H. - DOI - PMC - PubMed

[8] Tang T. M. S.; Luk L. Y. P. Asparaginyl endopeptidases: enzymology, applications and limitations. Org. Biomol. Chem. 2021, 19, 5048–5062. 10.1039/D1OB00608H. - DOI - PMC - PubMed

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Novel Haloacethydrazides as AEP Inhibitors for Treating Alzheimer's Disease

Affiliations

Novel Haloacethydrazides as AEP Inhibitors for Treating Alzheimer's Disease

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Abstract

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