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Review
. 2023 Aug 31;7(3):191-198.
doi: 10.1002/ped4.12395. eCollection 2023 Sep.

The update of treatment strategies in pediatrics with generalized pustular psoriasis in China

Yunliu Chen  1 , Xin Xiang  1 , Zhaoyang Wang  1 , Chaoyang Miao  1 , Zigang Xu  1
Affiliations
Review

The update of treatment strategies in pediatrics with generalized pustular psoriasis in China

Yunliu Chen et al. Pediatr Investig. .

Abstract

Generalized pustular psoriasis (GPP) is a severe subtype of psoriasis, commonly combined with systemic inflammation. Gene mutations have been found to be associated with GPP and vary by ethnicity. Systemic treatments are usually required for the severity and potential complications of GPP. However, there is no common consensus in China, especially among pediatric patients, whose data are scarce. Acitretin, methotrexate, and cyclosporine are widely used in pediatrics with GPP, while the adverse effects should be highlighted. The emergence of different biological agents brings us into a new era. This article discusses the genetic background of Chinese patients and demonstrates the evidence of treatment in pediatrics with GPP.

Keywords: Generalized pustular psoriasis; Pediatrics; Treatment.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

FIGURE 1
FIGURE 1
The clinical presentation of generalized pustular psoriasis.
See this image and copyright information in PMC

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