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Case Reports
. 2023 Aug 21;15(8):e43841.
doi: 10.7759/cureus.43841. eCollection 2023 Aug.

Acquired Non-histaminergic Angioedema With C1q Autoantibody and Urticaria: A Case Report

Andrew P Kochvar  1 , Gavin Cobb  1 , Celina C Bernabe  2 , Terry Levine  2
Affiliations
Case Reports

Acquired Non-histaminergic Angioedema With C1q Autoantibody and Urticaria: A Case Report

Andrew P Kochvar et al. Cureus. .

Abstract

Acquired angioedema (AAE) is a rare disease with life-threatening complications. This pathology has classically been associated with medication use and B cell lymphoproliferative disorders. In this report, we describe a 61-year-old man with a six-year history of angioedema, unrelated to any known triggers or malignancy. Extensive workup has led to a diagnosis of idiopathic nonhistaminergic AAE with normal C1 inhibitor. The patient is currently being treated with lanadelumab, which has resolved the patient's symptoms. This case provides insight into the onset, exploration, treatment, and outcomes of an extremely rare disease process.

Keywords: aae; acquired angioedema; anti-c1q antibody; autoimmune disease; bradykinin; c1q autoantibody; icatibant; inh-aae; lanadelumab; urticaria.

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Conflict of interest statement

The authors have declared financial relationships, which are detailed in the next section.

Figures

Figure 1
Figure 1. Angioedema attack of the upper lip and nares before (A) and after (B) icatibant administration
See this image and copyright information in PMC

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