Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023;26(10):1120-1130.
doi: 10.22038/IJBMS.2023.71915.15627.

Potential role of saffron and its components on miRNA levels in various disorders, a comprehensive review

Mohammad Reza Aslani  1   2 , Farshad Armin  1   2 , Ali Abedi  1   2 , Elham Keramati  1   2 , Hassan Ghobadi  1
Affiliations
Review

Potential role of saffron and its components on miRNA levels in various disorders, a comprehensive review

Mohammad Reza Aslani et al. Iran J Basic Med Sci. 2023.

Abstract

The potential therapeutic benefits of saffron and its active constituents have been investigated for the treatment of numerous illnesses. In this review, the impacts of saffron and its essential components on the levels of microRNAs (miRNAs) in different diseases have been delineated. Relevant articles were obtained through databases such as PubMed, Web of Sciences, Scopus, and Google Scholar up to the end of November 2022. miRNA expression has been altered by saffron and its active substances (crocin, crocetin, and safranal) which has been of great advantage in treating diseases such as cardiovascular, type 2 diabetes, cancers, gastrointestinal and liver disorders, central and peripheral nervous system disorders, asthma, osteoarthritis, ischemic-reperfusion induced injury conditions, and renal disorder. This study uncovered the potential restorative advantages of saffron and its derivatives, in miRNA imbalances in a variety of diseases.

Keywords: Crocetin; Crocin; Saffron; Safranal; miRNAs.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Biogenesis of miRNAs. pre-miRNA: precursor miRNAs, pri-miRNAs: primary miRNAs
Figure 2
Figure 2
A summary of the effects of saffron and its active ingredients in various disorders
See this image and copyright information in PMC

References

    1. O’Brien J, Hayder H, Zayed Y, Peng C. Overview of microRNA biogenesis, mechanisms of actions, and circulation. Front Endocrinol (Lausanne) 2018;9:402–414. - PMC - PubMed
    1. Akhavanakbari G, Babapour B, Alipour MR, Keyhanmanesh R, Ahmadi M, Aslani MR. Effect of high fat diet on NF-kB microRNA146a negative feedback loop in ovalbumin-sensitized rats. Biofactors. 2019;45:75–84. - PubMed
    1. Vasudevan S. Posttranscriptional upregulation by microRNAs. Wiley Interdiscip Rev RNA. 2012;3:311–330. - PubMed
    1. Dharap A, Pokrzywa C, Murali S, Pandi G, Vemuganti R. MicroRNA miR-324-3p induces promoter-mediated expression of RelA gene. PLoS One. 2013;8:e79467. - PMC - PubMed
    1. Bottini S, Hamouda-Tekaya N, Mategot R, Zaragosi L-E, Audebert S, Pisano S, et al. Post-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq. Nat Commun. 2017;8:1189–1205. - PMC - PubMed

LinkOut - more resources