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Review
. 2023 Nov;55(11):1531-1544.
doi: 10.1007/s00726-023-03326-w. Epub 2023 Sep 22.

Impact of chemical modifications on the antimicrobial and hemolytic activity of helical amphipathic peptide Lasioglossin LL-III

Hai Bui Thi Phuong  1 , Chi Le Uyen  1 , Hoa Doan Ngan  2 , Huy Luong Xuan  3   4
Affiliations
Review

Impact of chemical modifications on the antimicrobial and hemolytic activity of helical amphipathic peptide Lasioglossin LL-III

Hai Bui Thi Phuong et al. Amino Acids. 2023 Nov.

Abstract

Insect venom is abundant in potential antimicrobial peptides (AMPs), which can serve as novel alternatives to conventional antibiotics. Among them, Lasioglossin III LL-III) is a promising candidate with a broad spectrum against many fungi strains and both types of bacteria, whereas almost non-toxic to red blood cells. Many chemical approaches have been recently applied to improve its pharmacological properties and provide useful information regarding structure-activity relationships. Hence, this review focused on highlighting the lesson learned from each modification and supporting the future design of potent, selective, and metabolically stable AMPs.

Keywords: Amphipathic helix; Antimicrobial peptides; Chemical modifications; Hydrocarbon staples; Structure–activity relationships.

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