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Comment
. 2023 Sep 21;30(9):1004-1006.
doi: 10.1016/j.chembiol.2023.08.013.

Un-FASN-ing cancer's seat belt: Linking lipid metabolism and antigen presentation

Zachary Corey  1 , Elyse Schechter  1 , Raphael A Nemenoff  2
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Un-FASN-ing cancer's seat belt: Linking lipid metabolism and antigen presentation

Zachary Corey et al. Cell Chem Biol. .
Free article

Abstract

MHC-II expression on cancer cells is associated with improved treatment outcome. In this issue, Huang et al.1 report a panel of small molecules that selectively upregulate MHC-II on cancer cells through suppression of fatty acid synthase (FASN), resulting in inhibition of tumor growth. Targeting this link between lipid metabolism and antigen presentation may improve response to immunotherapy.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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